Denki Kagaku Kogyo Kabushiki Kaisha

Hitoshi Ikeya

Haruhiko Sato

Takenori Ishizawa

Tadashi Morikawa

Koichi Takahashi

Yoshinobu Higuchi

Tatsuya Tamura

Akira Okamachi

Hironoshin Kitagawa

Noriyuki Izutani

Akie Honma

Tatsuya Kato

An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.

Hyaluronic acid-methotrexate conjugate

An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.

An agent for treating a skin disease selected from the group consisting of a contact dermatitis treating agent, a xerosis senilis treating agent, an asteatosis treating agent, a housewives eczema treating agent, a keratosis treating agent, an eczema chronicum treating agent, a miliaria treating agent and a diaper rash treating agent, which contains hyaluronic acid and/or its salt having an average molecular weight of from 800,000 to 4,000,000, as an active ingredient.

Hyaluronic acid and its salt for treating skin diseases

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Machida, Japan

Hitoshi Ikeya