Daiichi Pharmaceutical Co., Ltd.

Hitoshi Iimori

Masanori Saito

Hideki Kubota

Satoru Miyauchi

Takanori Yasukouchi

Kayoko Motoki

Provided is a compound capable of inhibiting production or secretion of &#x3b2; amyloid protein. A compound represented by the following formula (1): (wherein, Rrepresents a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a hydrogen atom or a Calkyl group, and X represents &#x2014;S&#x2014;, &#x2014;SO&#x2014; or &#x2014;SO&#x2014;); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

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Tokyo, Japan

Hitoshi Iimori