Sankyo Company, Limited

Hitoshi Hotoda

Masakatsu Kaneko

Makoto Koizumi

Masatoshi Inukai

Hidehiko Furukawa

Kenji Momota

Tomoyuki Shibata

Akira Matsuda

Tomowo Kobayashi

Takuma Sasaki

Satoshi Ohya

Yukio Utsui

Yoshihiro Mitsuhashi

Yasunori Muramatsu

Toshio Takatsu

Masaaki Kizuka

Shunichi Miyakoshi

Masatoshi Arai

Yasumasa Ogawa

The present invention relates to a compound of formula (I) (wherein Rand Rrepresent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, Rrepresents a hydrogen atom or a hydroxyl group, and Xand Xrepresent an oxygen atom or a sulfur atom, or a nitrogen atom which may be substituted), a pharmaceutically acceptable derivative thereof or a salt thereof. The present invention also relates to a pharmaceutical composition comprising a compound described above as an active ingredient for the prevention or treatment of bacterial infections. The present invention includes the use of a compound described above in order to prepare a medicament effective in the prevention or treatment of bacterial infections. The present invention is concerned with a method for the prevention or treatment of bacterial infections in warm-blooded animals comprising administering a pharmacologically effective amount of a compound described above to them 

Antibacterial compound

Antimicrobial compounds

A composition and method of treatment or prophylaxis of a viral infection in a mammal, such as a human, are provided. The compounds in the composition and which are administered in the method, are oligodeoxyribonucleic acid derivatives of the formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups, and anthraquinonyl groups; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group or an aryl group; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or &gt;NH; Y.sub.2 is oxygen, sulfur, &gt;NH, alkylene or phenylene; X is an alkylene group; m and n are each 0 to 10; and B is an oligodeoxyribonucleotide of a chain length of 3 to 9, or salts thereof.

Composition and method for the treatment or prophylaxis of viral

Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.

Pyrimidine nucleoside derivatives having anti-tumor activity, their

Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or &gt;NH; Y.sub.2 is oxygen, sulfur, &gt;NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

Modified oligodeoxyribonucleoditides

Growing community of inventors

Tokyo, Japan

Hitoshi Hotoda