Jichi Medical University

Japan Science and Technology Corporation

Hitoshi Endo

Katsumi Kasashima

Yutaka Hanazono

Kaoru Tominaga

Tsukasa Ohmori

Yasumitsu Nagao

The present application relates to a method for reestablishing stem cells capable of forming chimeras, and cells obtained by the method. The method of the present invention is a technique for monocloning stem cells, for example, capable of forming chimeras from a heterogeneous cell population to obtain high-quality stem cells.

Method for reestablishment of pluripotent stem cells

The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.

Mitochondrial function of prohibitin 2 (PHB2)

The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.

Human mitochondrial proteins and polynucleotide encoding the proteins

Human mitochondrial proteins and polynucleotides encoding the proteins

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Tochigi, Japan

Hitoshi Endo