Nitto-denko Corporation

Toa Eiyo Ltd.

Sasaki Chemical Co., Ltd.

Kanebo, Limited

Teikoku Hormone Mfg. Co., Ltd.

Eisai R&d Management Co., Ltd.

Hitoshi Akemi

Saburo Otsuka

Takateru Muraoka

Takashi Kinoshita

Kazuhiro Higashio

Yoshifumi Hosaka

Keigo Inosaka

Akinori Hanatani

Yoshihiro Iwao

Yoshihisa Nakano

Kazuhisa Ninomiya

Junichi Sekiya

Hidetoshi Kuroda

Junichi Saito

Kensuke Matsuoka

Masato Nishimura

Yuji Saeki

Hiroko Ishitani

Yuichi Inoue

Mitsuhiko Hori

Katsuhiro Okada

Arimichi Okazaki

Kunio Tsukamoto

Fumiya Shirai

Masayoshi Kuniya

Toshiyuki Yamamoto

Sachiko Sakamoto

Shiro Satoda

Chiemi Mikura

Shunetsu Kikuchi

Yoshiteru Takahashi

Sachiko Terashi

Tomoko Matsushita

Yutaka Suzuki

Sumiyo Maruyama

Satoko Washiro

Sumiyo Nishi

The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.

Patch and patch preparation

The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

Adhesive preparation containing fentanyl

The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30&#xb0; C. of 0.2&#xd7;10to 10&#xd7;10Pa&#xb7;s and comprises two kinds of synthetic rubbers having different flowability.

Adhesive material and adhesive preparation

A manufacturing apparatus of a transdermal absorption preparation includes an adhesive sheet supplying part to feed out a band-like first adhesive sheet into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part to apply a given amount of a drug liquid to an adhesive face, and a traveling section for impregnation which is set in the runway after the drug liquid application part, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.

Manufacturing apparatus of transdermal absorption preparation

The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution. To be specific, the present invention is a patch package structure including a patchand a packaging memberholding the patch, wherein the patchincludes a supportand an adhesive layerformed on at least one surface of the support, the packaging memberincludes a first package, the first packageincluding an acrylonitrile resin layer, a moisture-absorbing layerformed on the acrylonitrile resin layer, and a moisture impermeable layerformed on the moisture-absorbing layer, and the acrylonitrile resin layeris provided on the proximal side of the patch

Patch package structure

The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution. To be specific, the present invention is a patch package structure including a patchhaving an adhesive layer containing an organic liquid component, and a packaging memberhousing the patch, wherein the packaging memberincludes a first package, the first packageincluding an acrylonitrile resin layer, a moisture-absorbing layerformed on the acrylonitrile resin layer, and a moisture impermeable layerformed on the moisture-absorbing layer, and the acrylonitrile resin layeris provided on the proximal side of the patch

The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.

Adhesive and laminate

An adhering member comprises an adhesive layerof a thickness R formed on one surface of a backing, and a linerof a thickness T laminated on the adhesive layer, and has a half-cut formed in the liner for making handleability satisfactory while preventing seepage of contents. The adhering member excellent in handleability and stability is obtained by providing, for example, the half-cuthaving a rectangular or inverted triangular sectional shape, a groove width of 200 &#x3bc;m or less, and a groove depth of more than 14T/15 but less than (T+R).

Adhering member and method for producing adhering member

The present invention provides an adhesive preparation superior in adhesion property, which does not peel off or fall off easily and which can be adhered for a long time. An adhesive preparationhas a supportmade of a cloth, and a pressure sensitive adhesive layerformed on one surface of the support, which contains a pressure sensitive adhesive and a drug. The ratio (CW/AW) of a mass (CW) per unit area of the supportand a mass (AW) per unit area of the pressure sensitive adhesive layeris 1.0-5.0, an adhesive layer-free surface of the supporthas a static friction coefficient of 0.25-0.75, and a 20% modulus (AM) in one direction of the adhesive preparationand a 20% modulus (EM) in the direction perpendicular to that direction are each 0.5-1.5 N/cm, and the ratio thereof (AM/EM) is 0.5-2.0.

Adhesive preparation

The present invention provides a medical adhesive tape and a tape preparation for percutaneous absorption, both having an adhesive layer that resists glue remainder and stickiness upon peeling off of the tape even after adhesion to the human skin for a long time, and a medical adhesive composition to be used for such tapes. The medical adhesive composition of the present invention includes, as essential elements, (A) a copolymer containing (a) alkyl (meth)acrylate, wherein the alkyl moiety has 4 to 18 carbon atoms, in a proportion of not less than 50 wt % of the copolymer and (b) a carboxyl group-containing vinyl compound in a proportion of 0.1 wt %&#x2013;10 wt % of the copolymer, (B) an alkoxide or a chelate compound of at least a metal selected from titanium, zirconium, zinc and aluminum, and (C) a polyol compound in a proportion of 0.2 wt %&#x2013;5 wt % of the aforementioned medical adhesive composition. The medical adhesive tape of the present invention and tape preparation for percutaneous absorption are characterized in that the adhesive layer contains the above-mentioned medical adhesive composition of the present invention.

Medical adhesive composition, medical adhesive tape using the same and tape preparation for percutaneous absorption

A medical adhesive sheet comprising a support and an adhesive layer formed on one side of said support, wherein the adhesive layer comprises an adhesive polymer having a weight average molecular weight of not less than 2,000,000, preferably not less than 2,500,000, and at least one plasticizer compatible with said polymer. The medical adhesive sheet of the present invention simultaneously satisfies the adhesive property to the skin and low irritation property, since it can retain the plasticizer in the adhesive layer, even without a crosslinking treatment. The effects of the present invention can be exerted irrespective of the kind of functional group that the plasticizer and drug have.

High molecular-weight medical adhesive with plasticizers, and product thereof

A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous-sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.

Medical adhesive sheet

The present invention provides a percutaneous absorption preparation which hardly causes the coloration phenomenon and is excellent in the stability of the drug content. The percutaneous absorption preparation comprises a support and a pressure-sensitive adhesive layer formed on at least one side of the support, wherein the pressure-sensitive adhesive layer contains a percutaneous absorptive drug and at least one of 2-mercaptobenzimidazole and propyl gallate, with the proviso that the percutaneous absorptive drug is not 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and pharmacologically acceptable salt thereof.

Percutaneous absorption preparation

Percutaneous preparation

A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.

Method for preparing a medical adhesive sheet

Growing community of inventors

Ibaraki, Japan

Hitoshi Akemi