Riken Corporation

The University of Tokyo

Hitomi Yuki

Shigeyuki Yokoyama

Tetsuo Nagano

Hirofumi Nakano

Akiko Tanaka

Hirotatsu Kojima

Masanao Abe

Takayoshi Okabe

Fumihiko Ishikawa

Yoriko Saito

Keiko Tsuganezawa

Yoshinobu Hashizume

Yasuko Koda

Teruki Honma

Nae Saito

This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Arand Areach represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C-alkylene; Zrepresents hydrogen, C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl; and Zrepresents C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl, Zand Zmay, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Zand Z.

Agent for treating or inhibiting recurrence of acute myeloid leukemia

An anticancer agent comprising a compound represented by the formula (I) [Rrepresents hydrogen atom, hydroxyl group, a Calkoxy group and the like; Rand Rrepresents hydrogen atom, a halogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group, a Calkylsulfonyl group and the like; Rrepresents hydrogen atom or a substituent;represents a single bond or a double bond; Rand Rrepresents hydrogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group and the like; A represents &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;CH&#x2014;; D represents &#x2014;C&#x2550; or &#x2014;N&#x2550;; X represents methylene group, &#x2014;O&#x2014;, or &#x2014;CO&#x2014;; Q represents &#x2014;N&#x2550; or &#x2014;C(R)&#x2550;; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase. 

Anticancer agent

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Kanagawa, Japan

Hitomi Yuki