Other

Takara Shuzo Co., Inc.

Takara Bio Inc.

Research Institute for Glycotechnology

Hitomi Kimura

Ikunoshin Kato

Takeshi Sakai

Katsushige Ikai

Kaoru Kojima

Yoshikuni Nakanishi

Kazuo Shimanaka

Sumiko Akiyoshi

Kaoru Katayama

Takanari Tominaga

Fu-Gong Yu

Shinji Nakayama

Hideo Kitano

An enzyme which decomposes a sulfated fucoglucuronomannan and is useful in the field of glycotechnology; a process for producing the enzyme; a fucoidan fraction reduced in the number of the kinds of molecules and useful as a reagent in glycotechnology; a sulfated fucoglucuronomannan oligosaccharide; and processes for producing the fraction and oligosaccharide.

Sulfated fucoglucuronomannan

Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

Apoptosis inducers

Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

Sulfated fucogalactan

Biologically pure culture of Fucoidanobacter marinus SI-0098 (FERM BP-5403)

An isolated endo-fucoidan-lyase is described. The enzyme acts on fucoidan, has a pH optimum from 6 to 10, and has an optimum pH from 30 to 40&deg; C. The enzyme can be isolated from Flavobacterium sp. FERM BP-5402. The enzyme is used to obtain sugar compounds which are useful in the study on carbohydrates.

Endo-fucoidan-lyase

Oligosaccharides from enzymatic cleavage of fucoidan

Growing community of inventors

Hirosaki, Japan

Hitomi Kimura