Kowa Company Limited

Hitomi Aoki

Toru Miura

Seiichi Sato

Tadaaki Ohgiya

Junya Tagashira

Ryohei Sekimoto

Rie Ishida

Hajime Yamada

Toshiaki Watanabe

Kazuhiro Onogi

Gen Watanabe

The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPAR&#x3b3; activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C&#x2014;Ror a nitrogen atom; Rrepresents an alkyl group; Rrepresents an alkyl group or a cycloalkyl group; and R, R, and Reach independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar. 

Phenylpyridine derivative and drug containing same

Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPAR&#x3b3;-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C&#x2014;Ror a nitrogen atom; Rrepresents a Calkyl group; Rrepresents a Calkyl group or a Ccycloalkyl group; and R, R, Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, a halo-Calkyl group, or a Calkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.

Phenylpyridine derivative and medicinal agent comprising same

Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPAR&#x3b3; activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; Rand Rindependently represent a Calkyl group; and each of Rto Ris absent or represents H, a halogen atom, OH, NO, a halo-Calkyl group, a (substituted) Calkoxy group, a (substituted) Ccycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]

Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same

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Higashimurayama, Japan

Hitomi Aoki