Genzyme Corporation

Hitesh R Bhagat

Jeffrey M Goldberg

Abizer I Harianawala

Louis Brenner

Jeffery Marc Goldberg

The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37&#xb0; C. and at pH of at least 1 for a period of at least ten weeks at 60&#xb0; C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.

Aliphatic amine polymer salts for tableting

A powder formulation comprises a pharmaceutically acceptable anionic stabilizer and an aliphatic amine polymer or a pharmaceutically acceptable salt thereof mixed with the anionic stabilizer. The powder formulation is conveniently packaged in a container, such as a sachet. A method of treating a subject with hyperphosphotemia with the powder formulation is also disclosed.

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Wayland, MA, United States of America

Hitesh R Bhagat