Astrazeneca Ab

Astrazenca Ab

Alcon Research, Ltd.

Hitesh Jayantilal Sanganee

Brian Springthorpe

Roger Victor Bonnert

Rukhsana Rasul

Aaron Rigby

Simon Teague

Louise Lawrence

Tony Cook

Mark Dickinson

Timothy Nicholas Birkinshaw

Christopher Luckhurst

Premji Meghani

Mark Furber

Tao Feng

Matthew Wd Perry

Stephen Brough

Austen Pimm

Andrew Whittaker

Hiroki Wada

Christopher De Savi

Rhona Jane Cox

Peter Cage

Simon Fraser Hunt

Linda Anne Stein

Glen Andrews

Daniel Jon Warner

Simon De Sousa

Frank Burkamp

Meghani Premji

The present disclosure relates to new therapeutic uses of MPO inhibitors and methods of treatment involving the same.

MPO inhibitors for use in medicine

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.

Phenoxypyridinylamide compounds

The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.

Pyrazine derivatives

The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders. 

Substituted indoles

The present invention provides compounds of formula (I) in which n, y, X, X, A, B, R, R, R, Rand Rare as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.

Compounds 010

The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders.

The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders. 

Indole-3-sulphur derivatives

The present invention provides a compound of formula (I), wherein: Z is (A) OR (B) and wherein the remaining variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of achemokine (such as CCR3) or H1 mediated disease state. 

Piperidine derivatives useful as modulators of chemokine receptor activity

The present invention provides a compound of formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state. 

The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity.

Chemical compounds

The invention provides compounds of formula (I): as modulators of chemokine and H1 receptor activity. The compounds are especially useful in the treatment of asthma and rhinitis.

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

The invention provides a compound of formula (I): T is C(O) or S(O); W is CH, (CH), CH(CH), CH(CH)O or cyclopropyl; X is O, CH, C(O), S, S(O), S(O)or NR; m is 0 or 1; Ris optionally substituted aryl or optionally substituted heterocyclyl; Ris alkyl (optionally substituted by OH), cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

Growing community of inventors

Loughborough, United Kingdom

Hitesh Jayantilal Sanganee