Axial Therapeutics, Inc.

Oravax-Merieux Co.

Hitesh Bhagat

Anthony Stewart Campbell

Ryan Barrett

Thomas P Monath

Harold Kleanthous

Farshad Guirakhoo

Samuel K Ackerman

Cynthia K Lee

Richard A Weltzin

Gopalan Soman

Jacques Pappo

William D Thomas

Ilene Sussman

Thomas Ermak

Described are sustained-release solid dosage forms of epigallocatechin gallate (EGCG) or aminosterol compositions. In one aspect of the invention the sustained-release solid dosage forms of EGCG or an aminosterol are capsules comprising a plurality of coated solid particulates. Another aspect of the invention relates to methods of inhibiting, ameliorating, reducing the likelihood of, delaying the onset of, treating or preventing an amyloid disorder, comprising the step of administering to a subject in need a therapeutically effective amount of the solid dosage form. In certain aspects, the amyloid disorder is Parkinson's Disease.

Sustained release solid dosage forms for modulating the colonic microbiome

Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.

Multimeric, recombinant urease vaccine

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Framingham, MA, United States of America

Hitesh Bhagat