United Therapeutics Corporation

Lung Biotechnology Pbc

Mannkind Corporation

Emergent Virology LLC

Lung Biotechnology Inc.

United Therapeutics Corporaiton

Hitesh Batra

Sudersan M Tuladhar

David A Walsh

Raju A Penmasta

Liang Guo

Vijay Sharma

Sri Harsha Tummala

Kenneth R Phares

Yi Zhang

Sanmin Yang

Patrick Poisson

Ken Phares

Elizabeth Ann Harris

Raju Penmasta

Robert M Moriarty

David Mottola

Urban Ramstedt

Tam Nguyen

Adam Marc Silverstein

Susovan Jana

Sudersan Tuladhar

Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Stable treprostinil prodrugs

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Prodrugs of treprostinil

Treprostinil prodrugs

Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl diketopiperazine.

Treprostinil derivatives and their use in pharmaceutical compositions

Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.

Synthesis of esuberaprost prodrugs

Prodrugs of treprosiinil

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Process to prepare treprostinil, the active ingredient in Remodulin&#xae;

Provided are novel treprostinil salts as well as methods for making treprostinil salts.

Salts of treprostinil

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin. The methods include heating the compound of Formula 2 at a temperature of 180&#xb0; C. to 185&#xb0; C. Wherein the heating comprises irradiating the compound of formula 2 with microwave radiation.

Synthesis of intermediates for producing prostacyclin derivatives

The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.

Method of producing beraprost

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Herndon, VA, United States of America

Hitesh Batra