Santen Pharmaceutical Co., Ltd.

Ube Industries, Inc.

Hisayuki Seike

Kazuo Nishimura

Takeshi Matsugi

Hiroyuki Aono

Atsushi Shimazaki

Masaaki Murai

Hidehito Matsuoka

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient

An object of the present invention is to find new pharmacological actions of urea compounds having structure represented by the general formula [1]. The urea compounds having the structure represented by the general formula [1] have excellent angiogenesis inhibitory actions. [wherein 'A' is &#x2014;(NR)&#x2014;, &#x2014;(CRR)&#x2014; or &#x2014;O&#x2014;, 'B' is alkylene or alkenylene, R, R, R, Rand Rare hydrogen, alkyl, alkenyl, adamantylalkyl or the like, Ris aryl or an unsaturated heterocycle, and X is oxygen or sulfur].

Angiogenesis inhibitor

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Ikoma, Japan

Hisayuki Seike