Zeria Pharmaceutical Co., Ltd.

Hisayoshi Kato

Yoshiaki Tanaka

Tomoji Aotsuka

Naoyoshi Miura

Naoki Nakata

Motoki Torizuka

Kuniyoshi Ogura

Mitsuo Soeda

Akihiro Okubo

Hiroyasu Nishioka

Heihachiro Arai

Hikari Morita

Noaki Nakata

Hikaru Morita

Arylalkanoylamine derivative and drug containing the same

Phenylalkanoylamine derivatives, process for preparing the same, and

Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Condensed benzene derivative

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Konan, Japan

Hisayoshi Kato