Taisho Pharmaceutical Co., Ltd.

Hisaya Wada

Katsuo Hatayama

Masakazu Sato

Toshihito Kumagai

Yasuji Yamada

Yoshinori Sekiguchi

Chihiro Yokoo

Hajime Asanuma

Tetsuo Takayama

Tatsuhiko Sano

Masabumi Shibuya

Koumei Ohta

Yoshihiro Migita

Yoshihiro Kimura

Takehiro Yamagishi

Taro Matsumoto

Hidemichi Mitome

Noriaki Murase

Hisahide Tanimoto

A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, which includes converting a compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof. 

Process for producing 3-alkoxy-2-amino-6-fluorobicyclo [3.1.0] hexane-2,6-dicarboxylic acid derivative and intermediate thereof

Aminobenzoic acid derivatives

To provide novel steroid derivatives having an antitumor action which can be synthesized efficiently and stereoselectively by means of synthetic organic chemistry. A steroid derivative represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 13 carbon atoms, A is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, X and Y together form an oxo group or an alkylenedioxy group having 2 or 3 carbon atoms, X is a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom or an alkoxy group having 1 to 5 carbon atoms, with the proviso that when X is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom, and when X is an alkoxy group having 1 to 5 carbon atoms, Y is an alkoxy group having 1 to 5 carbon atoms, or a salt thereof.

Steroid derivatives

Indolo[2,3-b]quinoxaline derivatives

Growing community of inventors

Toshima-ku, Japan

Hisaya Wada