Toyama Chemical Co., Ltd.

Hisatsugu Tsuda

Isamu Saikawa

Shohachi Murakami

Takako Hori

Hiroshi Sakai

Takashi Yasuda

Chosaku Yoshida

Joji Nakano

Ryuko Takeno

Yasuo Kiba

Jun Nitta

Sumiko Kishimoto

Toyoo Maeda

Hisashi Minami

Masatoshi Sugita

Yoshiko Yamamoto

Kenzo Tamai

Masahiro Takahata

Akira Yotsuji

Hidetada Mikami

Toshinori Ohashi

Novel substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases lower warm-blooded animals. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Novel substances having carcinostatic and immunostimulating activity,

Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human beings. This disclosure concerns such substances and a process for preparing the same and an antitumor agent containing the same.

Novel substances having antitumor and immunostimulating activity,

This invention relates to a process for producing a TF-500 substance having carcinostatic and immunostimulating activities, which comprises subjecting organisms belonging to the Fusobacterium genus to extraction treatment with a dialkyl sulfoxide and obtaining said TF-500 substance from the resulting extract.

Process for preparing substance having carcinostatic and

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition salts

Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or acid

Novel TF-2 substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human being. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Substances having carcinostatic and immunostimulating activity

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and a salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts thereof

4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, acid

A composition comprising a component obtained by deproteinizing an extract from the poison pouch contents of bee has an immunostimulating activity, a carcinostatic activity, an effect of enhancing the antibacterial activity of an antibacterial substance and an effect of enhancing the carcinostatic activity of a carcinostatic substance. This invention is directed to a carcinostatic, immunostimulating and antibacterial agent comprising said composition.

Pharmaceutical composition comprising extract from poison pouch contents

A method for treating a host mammal having a decreased immunity, comprising administering to said host mammal an immunostimulating effective amount of the deproteinized extract from the poison pouch contents of bee B-T, is disclosed.

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Toyama, Japan

Hisatsugu Tsuda