Ajinomoto Co., Ltd.

Japanese Foundation for Cancer Research

Hisashi Shinkai

Koji Ohsumi

Chikahiko Eguchi

Shigeshi Toyoshima

Takashi Tsuruo

Koji Toi

Yoshiko Seto

Izumi Kumashiro

Akira Kamimura

Hirozumi Eto

Kouzou Toyota

Agents against drug-resistant tumor cells comprising a 1,4-dihydropyridine derivative represented by the following formula (I): ##STR1## wherein R.sup.1 is an aryl group which may be substituted;

1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as

A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --CH(CH.sub.3)--OCO--R.sup.3, and --CH.sub.2 --OCO--C(CH.sub.3).sub.3 ; R.sup.2 is selected from groups comprising aryl of 6 to 12 carbon atoms, a hetero six-membered ring, a hetero five-membered ring, cycloalkyl, or cycloalkenyl, any of which groups may have one or more substituents; and R.sup.3 is selected from hydrogen and alkyl of 1 to 5 carbon atoms; the salts thereof, and precursors which can be converted thereto in the human or animal body. Some of the compounds are novel per se.

Hypoglycemic agent

Growing community of inventors

Tokyo, Japan

Hisashi Shinkai