Kyoto Daiichi Kagaku Co., Ltd.

Arkray, Inc.

Hisashi Okuda

Harumi Uenoyama

Michio Naka

Yoshihiko Higuchi

Kouji Hirayama

Masufumi Koike

Katsumi Hamamoto

Yoshiharu Sato

Kexin Xu

Yutaka Yamasaki

Yoshimi Oura

Koji Matsuoka

Mitsugi Senda

Masafumi Koike

Kotaro Kado

The present invention relates to a technique for measuring the concentration of a particular component in a sample liquid using a test tool (). The test tool () includes a first through a third detection elements (-) arranged in the mentioned order in the moving direction of the sample liquid for measuring an electro-physical quantity. The present invention provides a concentration measuring method which includes a first detection step for detecting whether or not liquid conduction is established between the first and the second detection elements (), a second detection step for detecting whether or not liquid conduction is established between the second and the third detection elements (), a measurement step for measuring an electro-physical quantity by using the first through the third detection elements (-), and a concentration computation step for computing the concentration of the particular component based on the electro-physical quantity. The present invention also provides a concentration measuring apparatus () for realizing the concentration measuring method.

Concentration measuring method and concentration measuring apparatus

A suction generating device for a sample analysis device is provided. The device comprises four parts, namely, a cover plate, a middle plate, a bottom plateand an operation plate. A protruding portionfor compressing the suction generating chamber is formed in an approximately center portion on the lower side of the operation plate, a protruding portionfor operation is formed in an approximately center portion on the upper side of the operation plate. A cavityfor inserting the sample analysis device therein is formed in an approximately center portion in the bottom plate; and a holefor light irradiation is punched in a determined portion in the cavity. A concave portionfor fitting the operation platetherein is formed in the middle plate, and a window sectionis formed in the center of the concave portionto let the lower protruding portionon the operation plateprotrude therethrough. A window sectionis formed in the cover plateto let the upper protruding portionon the operation plateprotrude therethrough.

Device for analyzing a sample

A measuring method for determination of the content of a substance in a specimen on the basis of the value of a physical property measured with the specimen in which the determination is influenced by another substance coexisting with the object substance in the specimen, characterized in that: the value of the physical property measured with the specimen with a known content Ht of the coexisting substance is corrected to a value Vc of the physical property calculated with a standard content value Hts as the content Ht of the coexisting substance on the basis of a correction table showing the relationship between the contents Ht of the coexisting substance and set values V of said physical property for the respective key contents of the object substance. The measuring method permits instantaneous determination with high precision of the content of a substance for which no calibration curve can be prepared because of the effects of a coexisting substance.

Method and apparatus for determination of a substance coexisting with another substance

A suction generating device for a sample analysis device is provided. The device comprises four parts, namely, a cover plate,a middle plate,a bottom plate,and an operation plate,A protruding portion,for compressing the suction generating chamber is formed in an approximately center portion on the lower side of the operation plate,a protruding portion,for operation is formed in an approximately center portion on the upper side of the operation plate,A cavity,for inserting the sample analysis device therein is formed in an approximately center portion in the bottom plate,and a hole,for light irradiation is punched in a determined portion in the cavity,A concave portion,for fitting the operation plate,therein is formed in the middle plate,and a window section,is formed in the center of the concave portion,to let the lower protruding portion,on the operation plate,protrude therethrough. A window section,is formed in the cover plate,to let the upper protruding portion,on the operation plate,protrude therethrough.

Suction generating device and sample analysis apparatus using the same

This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion,, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion,. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.

This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.

A light source pa light of a plurality of wavelengths of a near infrared region, and a spectroscopic part selects a wavelength subjected to absorption by lactic acid as a measuring wavelength from measuring light of a plurality of wavelengths emitted from the light source part. A probe comes into contact with an organism measuring portion and irradiates the organism measuring portion with the measuring light of the wavelength selected by the spectroscopic part, while a photoreceiving part detects transmitted/scattered light of the measuring light incident upon the organism measuring portion. A light signal detected by the photoreceiving part is converted to absorbance in a signal processing part, so that the concentration of lactic acid is calculated by a host computer serving as an arithmetic-control part and displayed on a display part. No reagent is required, while difference between lactic acid concentrations varied with measuring portions can also be noninvasively measured.

Method of and apparatus for measuring lactic acid in organism

There is provided a sensor for the measurement of a content of a material in liquid which material is oxidized with an oxidase enzyme in which sensor a reagent layer is formed on an electrode system composed of a measuring electrode and a counter electrode both of which are formed on an insulating substrate, the reagent layer is composed of a hydrophilic polymer layer comprising a hydrophilic polymer and a reactive layer comprising the oxidase enzyme and an electron carrier, and the reagent layer further comprises a phosphate.

Sensor and production method of and measurement method using the same

A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.

Biosensor and method of quantitative analysis using the same

A current-detecting type dry-operative ion-selective electrode having a working electrode and a counter electrode which are mounted on an insulating substrate, a first electrolyte layer containing a hydrophilic polymer and an ion-sensitive layer containing a hydrophobic polymer which are formed on the working electrode, and a second electrolyte layer containing a hydrophilic polymer which is laminated over the whole electrode system.

Current-detecting type dry-operative ion-selective electrode

A biosensor for electrochemically detecting an electrochemically active material generated by a reaction of a compound to be analyzed in a liquid sample and at least one compound which specifically reacts with the compound to be analyzed, in which a working electrode has at least two electrode parts and the supplied liquid sample contacts the electrode parts successively at an interval, and with which, the electrochemically active material and the compound to be analyzed are quantitatively analyzed separately.

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Kyoto, Japan

Hisashi Okuda