Banyu Pharmaceutical Co. Ltd

Msd K.k.

Hisashi Ohta

Hiroshi Kawamoto

Atsushi Satoh

Toshifumi Kimura

Satoshi Ozaki

Gentaroh Suzuki

Akio Sato

Satoru Ito

Osamu Okamoto

Masaya Hashimoto

Yasushi Nagatomi

Yukari Hirata

Yoshikazu Iwasawa

Takeshi Sagara

Kensuke Kobayashi

Hirokatsu Ito

Tomohiro Tsujita

Hiroki Sakoh

A compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: This compound has a metabotropic glutamate receptor 1 inhibitory effect, and therefore is useful for the treatment of a brain disorder such as convulsion, acute pain, inflammatory pain, chronic pain, cerebral infraction or transient cerebral ischemic attack, a mental dysfunction such as schizophrenia, and a disease such as anxiety and drug addition.

1,4-substituted piperazine derivatives

The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: 

Diaryl-substituted five-membered heterocycle derivative

The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ris a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; Ris halogen atom, a lower alkyl group, etc.; Qis carbon atom or nitrogen atom; Qis carbon atom which may be substituted with oxo group; the formula (III):&#x2003;&#x2003;(II)is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group &#x3b1;; and Ris hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

Biaryl derivatives

Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A, Aand Aindependently represent a carbon atom or a nitrogen atom, and one or two of A, Aand Arepresent a carbon atom; Rrepresents a lower alkyl group or the like; Rrepresents a phenyl group which may be substituted with a halogen atom or the like; Rrepresents a hydrogen atom, a lower alkyl group or the like; and Rrepresents a lower alkyl group or the like.]

Aryl-substituted nitrogen-containing heterocyclic compounds

The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I]  [in which A, A, A, Aand Astand for optionally halogen-substituted methine, or nitrogen atom; Rand Rstand for lower alkyl or the like; Rstands for hydrogen or lower alkyl; Rand Rstand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like] or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

4-oxoimidazolidine-2-spiropiperidine derivatives

The invention provides the compounds represented by the formula (I) 

N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives

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Tsukuba, Japan

Hisashi Ohta