Otsuka Pharmaceutical Company, Limited

St. Marianna University School of Medicine

Hisashi Nagamoto

Hiroshi Yamashita

Muneaki Kurimura

Takayuki Matsuzaki

Isao Takemura

Fujio Tabusa

Masatoshi Chihiro

Toyoki Mori

Kazuyoshi Kitano

Goro Miyakoda

Shinobu Sueyoshi

Kazuhide Ohta

Kazuo Sekiguchi

Katsumi Ikezono

Takashi Maeda

Masayuki Kohashi

Hiroshi Oka

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein Ris a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and Ris a group represented by the following general formula: (wherein R's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof represented by the general formula (1), wherein, Ris a phenyl group which may have 1 to 3 lower alkoxy groups as the substituents on the phenyl ring; Ris a pyridyl group which may have 1 to 3 carboxyl groups as the substituents on the pyridine ring.

Agent for curing chronic obstructive pulmonary disease

Novel pharmaceutical composition for accelerating salivation and for prophylaxis and/or treatment of xerostomia, which comprises as an active ingredient a carbostyril compound of the formula (1), wherein R is a halogen atom, and the substitution position of the subsistuent on said carbostyril nucleus is the 3- or 4-position, and the bond between the 3- or 4-positions of the carbostyril nucleus is either a single bond or a double bond, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention exhibits an accelerating activity of salivation, and is useful in the prophylaxis or treatment of Xerostomia or hyposalivation. 

Carbostyril derivatives for accelerating salivation

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula:

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Suita, Japan

Hisashi Nagamoto