Kowa Company Limited

Hisashi Kunieda

Masami Shiratsuchi

Masahiko Nagakura

Kiyoshi Kawamura

Toshihiro Akashi

Seiichi Sato

Yoshinori Kyotani

Hiromichi Shigyo

Yasumi Uchida

Noboru Shimizu

Naotoshi Sawada

Setsuro Fujii

Mitsuteru Hirata

Hiroshi Ishihama

Koichiro Watanabe

Eizou Hattori

Kazuhiro Onogi

By Takayasu Miwa, Heir

Naoki Machida

Naoki Machida, Deceased

Phenyl tetrahydronaphthylcarboxylate of the formula: ##STR1## wherein A is a direct bond, or a lower alkylene, vinylene or imino group; B is a direct bond, a lower alkylene or --NH-lower alkylene group, or an --OCH.sub.2 CO-- residual group; and R is a lower alkyl group, with the proviso that A and B are not direct bonds simultaneously, and A, B and R are not a lower alkylene group, a direct bond and a methyl group, respectively, at the same time, are effectively useful as chymotrypsin inhibitors.

1-isopropyl-4[(4-tetrahydro-1-naphthoyloxy

Benzoyl indolecarboxylates of the formula: ##STR1## where R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy; R.sup.2 is hydrogen, lower alkyl, acetyl or benzoyl; R.sup.3 is hydrogen or lower alkyl; and A is a direct bond, or lower alkylene or vinylene substituted at the 2-, 3- or 5-position of the indole nucleus, are effective agents as chymotrypsin inhibitors.

Benzoyl indolecarboxylates

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,

Aromatic aminoethanol compounds, and utilization thereof as

A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,

Dihydrobenzopyran compounds and pharmaceutical composition comprising

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,

Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate

A tetrahydroxanthone derivative represented by the general formula: ##STR1## wherein R is a hydrogen atom, a hydroxyl, cyano, lower alkyl, lower alkoxy, lower acyloxy, benzoyloxy or tetrazolyl group, or ##STR2## (R.sub.3 is a hydrogen atom, R.sub.4 is a hydrogen atom, a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.3 and R.sub.4 commonly form a ring together with the adjacent nitrogen atom and another nitrogen atom or an oxygen atom); R.sub.1 is a hydrogen or halogen atom, a lower alkyl, cyano, carboxyl or tetrazolyl group, or ##STR3## (R.sub.5 is a hydrogen atom, R.sub.6 is a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.5 and R.sub.6 commonly form a ring together with the adjacent nitrogen atom and an oxygen atom); and R.sub.2 is a hydrogen or halogen atom, or a lower alkyl group; with the proviso that neither R nor R.sub.1 is a hydrogen atom; when R is --CONH.sub.2, R.sub.1 and R.sub.2 are not respectively a hydrogen atom nor a hydrogen or halogen atom, or a lower alkyl group; and R.sub.2 and R.sub.1 are not respectively a hydrogen atom nor a halogen atom or a lower alkyl group. Exhibits anti-allergic, anti-inflammatory, analgesic, inhibitory and asthma-treating activities.

Tetrahydroxanthone derivatives

Methylmethioninesulfonium compounds of the formula ##STR1## wherein X.crclbar. represents an anion;

Methylmethioninesulfonium compounds, process for their preparation, and

Growing community of inventors

Higashimurayama, Japan

Hisashi Kunieda