Japan Tobacco Inc.

Amgen Inc.

Tularik Limited

Hisashi Kawasaki

Hiroyuki Abe

Shinichi Kikuchi

Jonathan B Houze

Frank Kayser

Rajiv Sharma

Tetsuya Iida

Toshiyuki Sakai

Mitsuru Takahashi

Takayuki Yamaguchi

Yoshikazu Hori

Kazuhide Hayakawa

Toyomichi Nanayama

Hironori Kurachi

Masahiro Tamaru

Takayuki Yoshida

Samuel Sperry

The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

Pyrimidine compound and medical use thereof

Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in lipid metabolism, inflammation and cell proliferation. The subject compounds are linked biaryl compounds.

Linked biaryl compounds

Growing community of inventors

Osaka, Japan

Hisashi Kawasaki