Other

Kuraray Co., Ltd.

Fuji Yakuhin Kogyo Kabushiki Kaisha

Hisashi Iwata

Lorne M Golub

Thomas F McNamara

Tetsuo Takigawa

Robert A Greenwald

Haruo Ito

Nangavarum S Ramamurthy

Kazushi Iwata

Goro Kobayashi

Michiya Shimamura

Tsutomu Kawai

Shigeo Maruno

Taro Hayakawa

Shuji Kodama

Kyoko Yamashita

Seiji Ban

Junichi Kishi

Takashi Hamasaki

Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula ##STR1## The method is effective in the treatment of various articular diseases characterized by excessive collagen destruction.

Method to reduce connective tissue destruction

Method for the diagnosis of rheumatoid arthritis

A biocompatible composite material comprising a substrate having a glass-hydroxyapatite ceramic layer disposed thereon, and optionally having an intermediate glass layer between the substrate and the layer. The glass-hydroxyapatite ceramic layer comprises a continuous glass phase having a hydroxyapatite ceramic dispersed therein, said hydroxyapatite ceramic having a calcium/phosphorous molar ratio of 1.50 to 1.75, wherein said hydroxyapatite ceramic is comprised mainly of hydroxyapatite. The surface portion of the layer is in a roughened state having voids and having the hydroxyapatite ceramic exposed. The composite material may be produced by a method comprising applying a blend of a powdery glass with a hydroxyapatite ceramic to the surface of a substrate with or without a glass layer disposed thereon, firing the resulting coated substrate and subjecting the fired coated substrate to an etching action with an acid. The composite material is useful as a bone substitute material for the reconsutrction of bone defects.

Biocompatible composite material and a method for producing the same

Growing community of inventors

Nagoya, Japan

Hisashi Iwata