Kyowa Hakko Kogyo Co., Ltd.

Hisashi Hosoe

Fumio Suzuki

Kenji Ohmori

Tadafumi Tamura

Kazuhiro Kubo

Yoshisuke Nakasato

Takeshi Kuroda

Ikufumi Yoshitake

A pyrazoloquinoline derivative having the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R.sup.4 is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. These compounds exhibit excellent anti-inflammatory activity and hepatic insufficiency treating activity.

Pyrazoloquinoline derivatives

Disclosed are naphthyridine derivatives represented by formula (I) ##STR1## wherein: X represents hydrogen; lower alkyl; aralkyl; substituted or unsubstituted aryl; substituted or unsubstituted aromatic heterocyclic group; --NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 independently represent hydrogen or lower alkyl; ##STR2## wherein W represents N or CH, Z represents a single bond, oxygen or NR.sup.3 (wherein R.sup.3 represents hydrogen, lower alkyl or benzyl) and n1 and n2 represent an integer of 1 to 3; or substituted or unsubstituted thiazolinyl; and

Anti-inflammatory 1,8-naphthyridin-2-one derivatives

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Shizuoka, Japan

Hisashi Hosoe