Sumitomo Chemical Company, Limited

Nihon Medi-physics Company, Limited

Hisao Tobiki

Hirotada Yamada

Kozo Shimago

Takenari Nakagome

Hiroshi Noguchi

Toshiaki Komatsu

Yasuko Eda

Akio Izawa

Norihiko Tanno

Iwao Nakatsuka

Shigeru Okano

Kenji Irie

Kosaku Okamura

Hiroaki Matsushima

Kousaku Okamura

Mitsuhisa Iinuma

Hideo Yamada

Takao Okuda

Sakae Okano

Yoshimasa Tanaka

Seiko Miura

Takayoshi Mitsunaga

Shozo Nakayama

Hitoshi Katayama

Kazutoshi Toya

Nobuo Uchiyama

Kiyokazu Jimpo

Toyozo Katsura

Yasushi Taira

Norithiko Tanno

Yutaka Mito

Takashi Harimoto

Shinzi Ueda

A sheath for a syringe barrel, includes a main body in which a radiation shielding device for holding a syringe filled with pharmaceutical liquid therein is fitted, a male luer provided at a front end of the main body and designed to set a disposable needle, and a transfixing needle extending backward from inside of the male luer to penetrate a rubber plug at an opening at a front end of a syringe held in the main body.

Sheath for syringe barrel

A luer needle unit and an injector effectively prevent a user's fingers from being hurt when a disposable needle is separated from the luer needle after use, while realizing simple and positive attachment of the luer needle to a supporting cap. Guide protrusions and guide recesses are provided between the luer needle and the supporting cap to prevent the rotation thereof. Guiding projecting portions are formed in the supporting cap to guide a needle part of the luer needle in the axial direction.

Luer needle unit and injector

A reagent feeder which can to be used in both a finger-push system and a slide system by only attaching and detaching a simple auxiliary component to and from a case body depending on the state of operation or a preference of the operator. The feeder includes a case body, a sphere discharge port and a discharge device, so as to discharge a sphere one by one by pushing down the discharge device. The discharge device is provided with an operation lever which extends out of the case body and can be pushed down by a finger. A slide cover surrounding an outer periphery of the case body is attached to the case body in such a way that it can be moved freely in a vertical direction and can be detached from the case body. The slide cover is engaged with the operation lever of the discharge device so that it can be moved integrally with the discharge device.

Reagent feeder

A double-sided needle assembly includes an insert needle for inserting into a vessel; an afflux needle for supplying pharmaceutical liquid in an injector to the insert needle; and a luer member. The member connects the insert needle with the afflux needle through a space defined between the ends of the needles in the member, and holds the insert and afflux needles to fit to the syringe of the injector under pressure. The confirmation of the insertion of the insert needle into the vessel is accomplished by observing the space of the luer member.

Double-sided needle assembly

An injector pre-filled with a radiopharmaceutical liquid, which comprises (1) a syringe containing a radiopharmaceutical liquid with a stopper made of an elastic material fitted at the top opening, (2) a holder having a hole at thee central part fitted on the stopper to keep it firmly at such position, (3) an adaptor having a body portion of which the lower part forms a cap portion, a passage for the radiopharmaceutical liquid penetrating the body portion and a hollow needle portion continuously extending from the passage to the lower direction, detachably fitted on the syringe, and (4) a disposable needle head comprising a needle having a passage for the radiopharmaceutical liquid therein and a cap portion, detachably fitted on the body portion of said adaptor to make a gap at the top part of the cap portion of the needle head, the cap portion of the needle head being at least partly made of an inside observable material.

Injector

Disclosed are tablets having clear marks including letters, figures and the like which are impressed thereon wherein a material different in color tone from the portion other than the mark portion is deposited in the impressed valley portion and if necessary, these tablets are further applied with a coating and a method for producing the tablets.

Tablets having clear impressed marks and method for making same

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or a (C.sub.1 -C.sub.4) alkyl group, X is a straight or branched chain C.sub.1 -C.sub.4 alkylene group and R.sub.2 is a carboxyl group or a sulfo group; and the pharmaceutically acceptable salts thereof exhibit strong inhibitory activities against a wide variety of Gram-positive and Gram-negative bacteria including Psendomonas aeruginosa, indolepositive Proteus and Enterobacter aerogenes, and also have an increased and prolonged serum level in a living body. The compounds are therefore useful as antibacterial agents for the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(substituted

Sodium 6-[D(-)-.alpha.-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido ]penicillanate or its hydroxylated derivative at the p-position of the phenyl group in a crude state can be purified efficiently through its dimethyl sulfoxide adduct.

Dimethyl sulfoxide adducts of penicillins

A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.3 group or an --S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial and prepared by the reaction of a compound of the formula (II),

N-acylamino-.alpha.-arylacetamido cephalosporins

N-acylamino-alpha-arylacetamido cephalosporins and antibacterial

A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an --S--Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

7-(.alpha.-(4-Hydroxy-1,5-naphthyridine-3-carbonamido)-.alpha.-ph

A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an -S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

7-(.alpha.-(4

A penicillin of the formula: ##STR1## (i.e. 6-[D-2-(3-hydroxypyridazine-4-carbonamido)-2-(p-hydroxyphenyl)acetamido]pe nicillanic acid), which is valuable as an antibacterial agent, a nutritional supplement in animal feeds and a therapeutic agent in poultry and mammals including man and is especially useful in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

Novel penicillin, and its preparation and use

A penicillin of the formula: ##STR1## wherein ##STR2## is a six-membered heteroaromatic ring containing 1 or 2 nitrogen atoms as the hetero atom, Y is hydrogen, lower alkanoyl or lower alkoxycarbonyl, R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkanoyl, benzoyl, lower alkylmercapto, hydroxyl, mercapto, hydroxy(lower)alkyl, halogen or cyano or R.sub.1 and R.sub.2 may link together to form a lower alkylene chain which may be substituted with an oxo group, and Z is phenyl, hydroxyphenyl, lower alkyl, cyclohexadienyl, thienyl or isothiazolyl, which is prepared by reacting a compound of the formula: ##STR3## wherein Z is as defined above or its derivative with a carboxylic acid of the formula: ##STR4## wherein ##STR5## and R.sub.2 are each as defined above or its reactive derivative, if necessary, followed by hydrolysis or acylation of the resulting product and/or elimination of any protective group and which is useful as an antimicrobial agent against various gram-positive and gram-negative bacteria including Pseudomonas.

Penicillins

Penicillins of the formula: ##STR1## wherein R is an unsubstituted phenyl group or a substituted phenyl group having one or more hydroxyl groups or a cyclohexadienyl group and A represents a monocyclic or polycyclic nitrogen-containing heterocyclic aromatic ring, which are useful as antimicrobial agents having a broad antimicrobial spectrum against gram-positive and gram-negative bacteria including Pseudomonas and can be produced advantageously from the phenacyl ester of 6-aminopenicillanic acid through a series of steps.

Growing community of inventors

Kobe, Japan

Hisao Tobiki