Hoffmann-la Roche Inc.

Hisao Shimada

Raffaello Masciadri

Helmut Link

Erwin Gotschi

Tsutomu Kamiyama

Junko Watanabe

Mikio Arisawa

Paul Hebeisen

Toru Okuda

Miyako Masubuchi

Paulfaello Hebeisen

Hitomi Tanaka

Masae Kikuchi

Physiologically active caledothricins A-I and their salts, which are useful for the treatment of mycotic diseases. Also strains belonging to the genus Pseudomonas capable of producing the caledothricins upon cultivation.

Caledothricins used in the treatment mycotic diseases

Bicyclic derivatives of the general formula ##STR1## wherein X.sup.1 is --S-- or --SO--;

Process for the preparation of DNA gyrase inhibitors

Compounds of the formula ##STR1## in which P is hydroxy and T is the group -X.sup.2 -CR.sup.7a R.sup.7b -CHR.sup.8 -OH or T is hydrogen and P is the group O-CHR.sup.8 -CR.sup.7a R.sup.7b -X.sup.2 -OH and, wherein X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7a, R.sup.7b, and R.sup.8 are as defined in the specification, or a reactive derivative thereof. These compounds are useful in the preparation of DNA gyrase inhibitors.

DNA gyrase inhibitors, process for their manufacture and pharmaceutical

DNA gyrase inhibitors and pharmaceutical preparations therefor

The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.

Microorganism of genus eupenicillium

Antifungal agents

Growing community of inventors

Fujisawa, Japan

Hisao Shimada