Nippon Hypox Laboratories Inc.

Sawai Pharmaceutical Co., Ltd.

Dainippon Ink and Chemicals, Incorporated

Other

Sunstar Kabushiki Kaisha

Kabushiki Kaisha Med-Creat

Hisao Kakegawa

Toshio Satoh

Hitoshi Matsumoto

Yasunori Niiro

Yoshiko Kato

Junji Yoshinaga

Juichi Riku

Yoshifumi Kanamoto

Kenji Hasegawa

Toshio Sato

Tokutaro Miki

Takashi Asai

Yukimitsu Masamoto

Hideki Miyataka

Food composition

Ascorbic acid derivative

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.

Ascorbic acid derivative and use as antioxidant

Therapeutic agent for penal disorders

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.

Ascorbic acid derivative and use as antioxidants

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned novel ascorbic acid derivative or other known ascorbic acid derivatives.

Compounds of the general formula: ##STR1## wherein R.sup.1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R.sup.2 is hydrogen, halogen, or nitro, and R.sup.3 is carboxy group or its functional derivative, with the proviso that when R.sup.1 is an unsubstituted furyl, or furyl mono- or polysubstituted with alkyl and R.sup.2 is hydrogen, then R.sup.3 is functional derivative of carboxy and, where applicable, pharmaceutically acceptable salts thereof are hyaluronidase inhibitors and useful as anti-allergic agent.

Acrylamidobenzoic acid derivatives and their use

The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.

Benzothiazine-1,1-dioxide derivatives

Medicines for use in the therapy and prevention of kidney and liver

This invention relates to pharmaceutical compositions of compounds of the general formula: ##STR1## wherein R.sup.1 is an aryl group or a substituted aryl group wherein the substituent is halogen, hydroxy, C.sub.(1-6) lower alkoxy, C.sub.(1-6) lower alkylenedioxy, halo C.sub.(1-6) lower alkyl, cyano, nitro, mono- or di-C.sub.(1-6) alkylamino or C.sub.(1-6) lower alkanoylamino; or a 5-membered or 6-membered C.sub.(1-6) alkyl substituted or unsubstituted heterocyclic group containing a heteroatom selected from oxygen, nitrogen, and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, and R.sup.2 and R.sup.2' are, independently, hydrogen, halogen, nitro, C.sub.(1-6) lower alkyl or C.sub.(1-6) lower alkoxy. These compounds have been found to exhibit hyaluronidase inhibiting activity, anti-allergic activity and anti-ulcerous activity. The present invention further contemplates processes for the preparation of said compounds and their pharmaceutical compositions.

Pharmaceutical compositions of-2,2-1,1-[bis-2,2'-(3,1-benzoxazin-4-one)9

Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,

Pharmaceutical compositions of

A guanidinomethylbenzoic acid derivative represented by the formula ##STR1## or a salt thereof. An antiulcer agent comprising the compounds of the afore-said formula as an effective ingredient is also disclosed.

Novel guanidinomethylbenzoic acid derivatives

[(1,3-dioxo-1,3-propanediyl)diimino)]bisbenzoic acid derivatives

A pharmaceutical composition for producing antiallergic activity containing as an active ingredient a certain tocopherol derivative having a sugar residue at 6-position of the 3,4-dihydrobenzopyrane ring thereof. A method for producing antiallergic activity using such a tocopherol derivative and some novel tocopherol derivatives are also disclosed.

Growing community of inventors

Tokushima, Japan

Hisao Kakegawa