Nippon Kayaku Kabushiki Kaisha

Other

Orion-yhtyma Oy

Institute of Medicinal Molecular Design, Inc.

Tmrc Co., Ltd.

Hisao Ekimoto

Lauri V Kangas

Tetsushi Saino

Osamu Miyazaki

Anni Warri

Michinori Koyama

Christer Granberg

Junpei Itoh

Katsutoshi Takahashi

Masanobu Suzuki

Osamu Kogawa

Yukio Irie

Akio Fujii

Yuichi Hashimoto

Tadashi Ishii

Hiroyuki Kagechika

Hideji Fujii

Tokuji Nakatani

Masao Onishi

Keizou Ishikawa

Chieko Seno

Takeshi Nakanishi

Kenji Iwata

Minoru Noji

Takao Izawa

Miyoji Hanaoka

Junpei It&ouml;h

Ko Bando

Yoshimasa Senoo

Teruyuki Sakai

Kazuo Ootsuki

Yoshiaki Yonekawa

Kimihiko Takada

Fumiko Kobayashi

The present invention provides a practical preparation form of Tamibarotene and dosage form thereof, which exhibit high absorptivity by the body with minimized toxicity, and which are safe and stable without any risk of contamination. It is provided a Tamibarotene capsule preparation which encapsulates a composition comprising an oil component as its base and Tamibarotene as an active ingredient dissolved in the base. It is preferred that the oil component be propylene glycol fatty acid esters or polyethylene glycols. It is also preferred that the Tamibarotene capsule preparation comprise 0.1-50 mg/mL of the Tamibarotene based on the oil component.

Tamibarotene capsule preparation

Effective treatment of tumors, especially carcinomas, can be achieved by administering to man a photochemotherapeutic agent containing as an active ingredient a compound showing maximum absorption in the wavelength region of 800 to 1,200 nm, and then applying light rays of a wavelength of 800 to 1,200 nm.

Remedies for photochemotherapy

Remedies for diabetes

Disclosed is use of nonsteroidal anti-estrogen compounds such as toremifene citrate as active ingredient for treating autoimmune diseases.

Remedy for autoimmune diseases

The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.

Process for preparing benzo�c!phenanthridinium derivatives, novel

A platinum (II) complex represented by the general formula: ##STR1## [wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent ##STR2## (wherein m is 0, 1 or 2; n is 0 or 1; R.sub.1 is a C.sub.3 -C.sub.6 alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent ##STR3## (wherein R.sub.2 is a C.sub.2 -C.sub.5 alkyl group substituted with one hydroxyl group)]. These platinum (II) complexes have high potencies for use as an antitumor agent.

Platinum complexes

Disclosed is an agent for prevention and remedy of injuries caused by ischemia, which comprises, as an active ingredient, an SOD-containing liposome comprising a superoxidase dismutase (SOD) retained in a liposome having an electrically neutral or negative membrane.

Agent for prevention and remedy of injuries caused by ischemia

This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):

Selenium oxy chloride-pyridine or bipyridine complexes

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Tokyo, Japan

Hisao Ekimoto