Sumitomo Chemical Company, Limited

Hisao Akiyama

Shigeru Okano

Hiroyuki Suzuki

Yasuhiko Aoki

A new method for the production of intermediates in the synthesis of an optically active biotin, which comprises reacting a dicarboxylic acid of the formula: ##SPC1## Or its reactive derivative with an optically active primary amine, reducing the resulting trione with a metal hydride, hydrolyzing the resultant amide-alcohol and treating the thus produced lactone with a thiolactonating agent to give a thiolactone of the formula: ##SPC2## , the said trione and amide-alcohol being respectively novel and representable by the formulae: ##SPC3##

Method for synthesis of optically active thiolactones

In the conversion of a hexahydrofuro[3,4-d]-imidazole-2,4-dione compound into the corresponding hexahydrothieno[3,4-d]imidazole-2,4-dione compound, an improved process which comprises reacting the starting hexahydrofuro[3,4-d]imidazole-2,4-dione compound with a dithiocarbamate.

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Nishinomiya, Japan

Hisao Akiyama