Chugai Seiyaku Kabushiki Kaisha

Hisanori Takanashi

Tsutomu Sato

Hiroshi Koga

Osamu Cynshi

Toshiro Kozono

Tatsuhiko Iwase

Ken-ichiro Kotake

Eiji Kumagai

The present invention provides a therapeutic and/or preventive agent against gastroparesis symptom which is appropriate for continuous medication and which comprises a compound represented by formula (1): (wherein Rrepresents a C-Calkyl group and Rrepresents a C-Calkyl group) or a pharmaceutically acceptable salt thereof as an active ingredient. The erythromycin derivative of the formula (1) has an efficacy of improving gastroparesis and this action of the derivative in improving gastroparesis symptom is not found in ABT-229, a different motilin agonist erythromycin derivative. Further, the compound of the formula (1) is also appropriate for long-term clinical use because of its much weaker antibacterial action than that of erythromycin. Accordingly, the present invention provides a pharmaceutical agent that is safe and exhibits potent therapeutic and/or preventive effect in an effort to improve symptomatic gastroparesis.

Drugs for the treatment and/or prophylaxis of gastroparesis symptom

The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides compounds represented by the general formula (1):

Phenethylamine derivatives

Remedies for peripheral circulation disturbances

Erythromycin derivatives

Growing community of inventors

Tokyo, Japan

Hisanori Takanashi