Sankyo Company, Limited

Daiichi Sankyo Company, Limited

Hisaki Kajino

Yutaka Ikeuchi

Takao Okazaki

Hiroshi Miyamoto

Toshiaki Yanai

Seigo Iwado

Shuji Takahashi

Keiji Tanaka

Hiroshi Yasuda

Kazuo Sato

Toshiyuki Konosu

Sadao Oida

Hideo Takeshiba

Noriko Takeda

Junzo Tobitsuka

Yukiyoshi Takahi

Hiroshi Ohta

Shinji Matuura

Rei Okazaki

Eiji Numagami

Keijiro Kobayashi

Hiroyuki Itoh

Tomoyuki Nagai

To provide a hydrochloride of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90 and a crystal thereof. The present invention provides a hydrochloride of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a crystal thereof, a medicament comprising the same, an anticancer agent comprising the same, and the like.

Crystal of tricyclic pyrazolopyrimidine derivative

It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I). [Formula 1] 

Crystalline forms of thiazolidinedione compound and its manufacturing method

A compound having the following formula (III) wherein Ris hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.

Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same

A method for preparing a compound having the following formula (I) by reducing a nitro group of the following formula (III) followed by carrying out an intramolecular dehydration condensation, wherein Ris hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen.

Intermediate of 6-substituted 1-methyl-1-H-benzimidazole derivative and method for producing same

Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;

Macrolide compounds, their preparation and their use

Compounds of formula (I): ##STR1## [in which: R.sup.1 and R.sup.2 are hydrogen or alkyl, or together are cycloalkyl; R.sup.3 and R.sup.4 are hydrogen, alkyl or phenyl, or together are cycloalkyl; or R.sup.1 and R.sup.3 together are cycloalkyl fused to the oxetane ring; Ar is phenyl substituted by R.sup.5, R.sup.6 and R.sup.7, where R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl, alkoxy, halogenated alkyl or halogenated alkoxy; and R.sup.8 and R.sup.9 are hydrogen or alkyl] and salts thereof have valuable agricultural and pharmaceutical anti-fungal or fungicidal activity. They may be prepared by a variety of processes.

Oxetane derivatives and their use as anti-fungal or fungicidal agents

Growing community of inventors

Kanagawa, Japan

Hisaki Kajino