Hisamitsu Pharmaceutical Company, Inc.

Hisamitsu Pharmaceuticals

Hisakazu Kurita

Naruhito Higo

Tetsuro Tateishi

Yasunari Michinaka

Toshiro Yamaguchi

Tatsuaki Suzuki

Eisuke Hatanaka

Ryusuke Fudoji

Akio Takeuchi

Hideharu Chono

Junji Noguchi

Naoto Kamakura

A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

Patch

The purpose of the invention is to produce an imidafenacin-containing percutaneously absorbed preparation, wherein the drug not only is not allowed to crystallize but also has adequate skin penetration. The imidafenacin-containing percutaneously absorbed preparation comprises isostearic acid and a fatty acid ester, which function as crystallization-preventing agents.

Percutaneously absorbed preparation

A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.

Patch formulation for external use

Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm)and a have a very excellent skin permeability of the drug.

Preparations for percutaneous absorption

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Tsukuba, Japan

Hisakazu Kurita