Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Mochida Pharmaceutical Co., Ltd.

Hisahiro Ishiwari

Ryo Tanaka

Yukio Shimazaki

Kiyoshi Sakai

Yasuhito Tanaka

Miyuki Kawashima

Masahiko Ishibashi

Miki Suzuki

Nobuhiro Kawashima

Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

Aqueous solution of t-PA

A thrombolytic composition containing tissue type plasminogen activator or a derivative thereof in combination with an anionic polymer or a salt thereof and an amine compound or a salt thereof or in combination with an anionic polymer or a salt thereof, an amine compound and an acid or a salt thereof. The composition is an aqueous solution or a lyophilized preparation which can be stably dissolved on dilution at near neutral pH in both pharmaceutical solutions having high salt concentrations, such as physiological saline, and pharmaceutical solutions having low salt concentrations, such as a 5% glucose solution. Clinically useful products for infusion or injection are prepared to be used at a pH near neutral.

Method of improving solubility of tissue plasminogen activator

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Fujieda, Japan

Hisahiro Ishiwari