Nitto Boseki Co., Ltd.

National Institute of Agrobiological Sciences

Unitech Co.,ltd.

Hisae Arai

Katsuhiro Katayama

Tatsuya Ohashi

Toshiki Tamura

Iwao Kiyokawa

Keiro Uchino

Isao Kobayashi

Toshio Kanda

Noriyuki Funahashi

Masaji Ohno

Hisao Kondo

Ikuko Arai

The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose expression is regulated directly or indirectly by the promoter, and which secrete the recombinant antibody into the silk gland. The recombinant antibodies produced from the silk gland of the transgenic silkworms were confirmed to be active.

Antibody-producing transgenic silkworms and methods for producing the same

A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonane-1,6-diamineplatinum(II) complex which is represented by a following general formula (A). (In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z).) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.

Platinum complex and pharmaceutical composition containing the same

Growing community of inventors

Kashiwa, Japan

Hisae Arai