Prostec Co., Ltd.

Nippon Chemiphar Co., Ltd.

Kringle Pharma Inc.

Hiroyuki Tsuchiya

Masatsugu Maejima

Matsufumi Takaya

Yukinobu Hashimoto

Akihiko Takeuchi

Kunio Matsumoto

Mitsuyoshi Yamashita

Keigo Hanada

Katsuro Tomita

Natsumi Kageyama

Katsuhiko Kitaoka

Junsuke Nakase

Keita Ishimizu

Matsufumi (deceased) Takaya

Provided is an antibacterial biological implant capable of exhibiting superior antibacterial activity stably over a long period of time. The antibacterial biological implantincludes a substratemade of a metal material and an anodized coatingprovided on the substrate, the anodized coatingincluding an iodine-rich layerlocated close to an interface S between the anodized coatingand the substrate

Antibacterial biological implant

Provided is an antibacterial biological implant capable of exhibiting superior antibacterial activity stably over a long period of time. Also provided is a method for producing an antibacterial biological implant, the method including subjecting a substratesuccessively to an anodization treatment, an acid treatment, and an iodine treatment to obtain an antibacterial biological implant

Method for producing antibacterial biological implant

A method of producing metallic medical supplies includes supplying a metallic material selected from the group consisting of Ti, a Ti alloy, stainless steel and a Co&#x2014;Cr alloy as a base material; treating the base material by carrying out anodic oxidation treatment in which an acid electrolytic bath or an alkali electrolytic bath is used as an electrolytic solution, and pulsed current having a frequency of 50 to 10,000 Hz is applied to the base material in the electrolytic solution to carry out electrolysis treatment to form a film having micro pores and/or micro unevennesses having a density of 5&#xd7;10/mmor more on a surface of the base material; and carrying out iodine-impregnation treatment to impregnate the film with iodine or iodine compounds, wherein the metallic medical supplies have an antimicrobial activity value of not less than 2 to not more than 4.

Medical supplies and method of producing the same

The present invention provides a prophylactic or therapeutic agent for giant cell tumors occurring in a bone and soft tissue or for chondrosarcoma, which comprises a non-steroidal anti-inflammatory agent or thiazolidine derivative as an active ingredient, and the like.

Prophylactic or therapeutic agent for giant cell tumors occurring in bone and soft tissue or for chondrosarcoma

The present invention provides an agent for prophylactic treatment, therapeutic treatment, or prevention of metastasis of giant cell tumor occurring in a bone and soft tissue, chondrosarcoma, or bone sarcoma, a local infusion for artery embolization, and an artificial bone, which comprises a substance having a PPAR&#x3b3;-agonistic activity and/or a PPAR&#x3b3; expression-inducing activity as an active ingredient. The agent for prophylactic treatment, therapeutic treatment, or prevention of metastasis, the local infusion for artery embolization, and the artificial bone of the present invention are a radical therapeutic agent or radical therapeutic material that can cause apoptosis in giant cell tumor occurring in a bone and soft tissue, chondrosarcoma, or bone sarcoma to make the tumor disappear, and can induce differentiation of the tumor into fat cells to make the tumor disappear.

Drug for preventing, treating or preventing metastasis of giant cell tumor that occurs in bone or soft parts, chondrosarcoma, or osteosarcoma, local injection for arterial embolization, and artificial bone

A method of producing metallic medical supplies includes supplying a metallic material as a base material; treating the base material by carrying out any one of electrochemical treatment, chemical treatment, thermal and/or mechanical treatment or a combination of two or more of these treatments to form a film having micro pores and/or micro unevennesses having a density of 5' 104/mm2 on a surface of the base material; and carrying out iodine-impregnation treatment to impregnate the film with iodine or iodine compounds.

An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient:

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Kanazawa, Japan

Hiroyuki Tsuchiya