Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Hiroyuki Suzuki

Fumihiro Ozaki

Kohei Sawada

Takashi Yoshinaga

Kiyoaki Kobayashi

Tatsuhiro Onogi

Koki Kawano

Yoshihiko Norimine

Mutsuko Ono

Hiroe Minami

Toshihiko Kaneko

Yoshinori Takahashi

Masayuki Matsukura

Kazuki Miyazaki

Ichiro Yoshida

Hiroki Ishihara

Junichi Kamata

Hiroshi Katoh

Mutsuko Tabata

Miyuki Ohkubo

Compounds represented by the following general formula: [wherein X, X, Xand Xeach independently represent a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(=Q)- (wherein Qrepresents oxygen, sulfur or &#x2550;N&#x2014;R(wherein Rrepresents hydrogen or Calkyl)) and nitrogen, etc.; and Zrepresents piperidin-diyl, etc.],salts thereof and hydrates of the foregoing.

Nitrogen containing heterocyclic compounds and medicines containing the same

The present invention provides compounds represented by the following formula:wherein X, X, Xand Xeach independently represents a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(&#x2550;Q)&#x2014;, Qwherein represents oxygen, sulfur or &#x2550;N&#x2014;R, wherein Rrepresents hydrogen or Calkyl etc.; and Zrepresents piperidin-diyl, ect, salts thereof and hydrates of the foregoing.

Piperidine compound and pharmaceutical composition thereof

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Tsukuba, Japan

Hiroyuki Suzuki