Taiyo Yuden Co., Ltd.

Sony Corporation

Nippon Oil Company

Agilent Technologies, Inc.

Nec Corporation

Japan Polypropylene Corporation

Hewlett-Packard Company

Nippon Mitsubishi Oil Corporation

Hewlett-Packard Development Company, L.p.

Sony Semiconductor Solutions Corporation

Showa Denko K.k.

The University of Tokyo

Kyb Corporation

Tomy Kogyo Co., Ltd.

Kayaba Industry Company, Ltd.

Hiroyuki Shimizu

Akira Sano

Sumiaki Kishimoto

Kazuo Matsuura

Masaki Takase

Tomohiro Harada

Yukihiro Konishi

Koji Kunii

Takayuki Goto

Yutaka Doshida

Takeichi Shiraishi

Tomonori Nakajima

Takashi Seki

Shigeo Ishii

Toshikazu Yoshida

Masaharu Torikai

Keiichi Hatano

Minoru Kobayashi

Hiroshi Hamada

Masaru Fujii

Hideshi Uchino

Takahiko Kawatani

Yukihiro Matsui

Katumi Usui

Mitsuru Ikeda

Takahiro Furuya

Shingo Ito

Shinya Nakagawa

Yoshikuni Okumura

Toshihiro Nakashima

Kazuhiro Yamamoto

Kenji Soejima

Yusuke Ota

Kyoko Nozaki

Junichi Kuroda

Naoshi Iwama

Kunihiro Suzuki

Hiroaki Mori

Tomohiro Nishimura

Miyuki Matsumoto

Shinichi Tanida

Mitsuo Okamoto

Tetsuya Morioka

Akihiro Koube

Kazunari Abe

Yuichi Namikawa

Yuuhei Ueyama

Yasunari Takiguchi

Ryo Ito

Naoki Inoue

Takahiro Katayama

Masahiro Uematsu

Tamotsu Takahashi

Toshiaki Egashira

Gouki Watanabe

Yoshiyuki Bessho

Kiyoshi Chikamatsu

Minoru Uchida

Tomiyuki Hirose

Sinichi Yanahashi

Asa Yamamoto

Katsumi Usui

Yuuji Washio

Kohsuke Hazeyama

Takamasa Nagatomo

Masafumi Koyano

Kiyohiko Nakajima

Tetsuro Fukuda

Shiraishi Takeichi

An object of the present invention is to provide an effective vaccine capable of preventing and treating congenital infection with CMV. The vaccine for preventing or treating congenital infection with cytomegalovirus (CMV) according to the present invention comprises a CMV envelope glycoprotein B (gB protein) antigen and a pentamer antigen.

Vaccine for preventing or treating congenital infection with cytomegalovirus

The present invention is directed to provide a modified CMV gB protein that can induce a group of antibodies including a high ratio of neutralizing antibodies that exhibit a high neutralizing activity against a CMV gB protein, in comparison with a wild type CMV gB, upon induction of immunity and that can be used in the prevention and/or treatment of CMV infection and a CMV vaccine comprising the modified CMV gB protein. The modified CMV gB protein according to the present invention is a modified CMV gB protein having an improved ability to induce body region-recognizing antibodies and comprising modification in a head region.

Modified CMV gB protein and CMV vaccine including same

A multilayer piezoelectric ceramic is such that: its piezoelectric ceramic layers do not contain lead as a constituent element, and have a perovskite compound expressed by the composition formula LiNaKNbO(where 0.02<x≤0.1, 0.02<x+y≤1), as the primary component; and the internal electrode layers are constituted by a metal containing silver by 80 percent by mass or more, and contain ceramic grains containing the same elements found in the primary component. The multilayer piezoelectric element has a long lifespan, and whose internal electrode layers have a high content percentage of silver.

Multilayer piezoelectric ceramic and method for manufacturing same, multilayer piezoelectric element, as well as piezoelectric vibration apparatus

A multilayer piezoelectric element includes a ceramic body formed by a piezoelectric ceramic, and having first and second end face facing a longitudinal direction, first and second principal faces facing a thickness direction perpendicular to the longitudinal direction. A pair of external electrodes cover the first and second end faces, extend from the first and second end faces onto the first principal face via ridge parts connecting the end faces with the principal faces, and project in the thickness direction on the first principal face. Multiple internal electrodes are stacked inside the ceramic body and are connected alternately to the pair of external electrodes along the thickness direction. A surface electrode is provided on at least one of the first and second principal faces, and connected to the external electrode different from the one to which the internal electrode adjacent in the thickness direction is connected.

Multilayer piezoelectric element, piezoelectric vibration apparatus, and electronic device

A driving device generates a driving signal and outputs the driving signal to a piezoelectric element, the driving signal having a waveform obtained by using, as a first modulated wave, a first low-frequency wave having a frequency of 1 Hz or more and less than 100 Hz, using, as a second modulated wave, a waveform obtained by modulating an amplitude of a second low-frequency wave having a frequency of 100 Hz or more and 300 Hz or less with the first modulated wave, and modulating a high-frequency wave having a frequency of 20 kHz or more and 100 kHz or less with the second modulated wave.

Driving device, tactile sensation providing apparatus, and driving method

Provided is a driving apparatus that sets a signal wave in a low-frequency region having a frequency of 10 Hz or more and 250 Hz or less as a modulating wave and outputs to a piezoelectric actuator a driving signal having a waveform obtained by modulating an amplitude of a sine wave in a high-frequency region having a frequency of 20 kHz or more and 40 kHz or less with the modulating wave.

Driving apparatus, vibration generating apparatus, electronic apparatus, and driving method

A multilayer piezoelectric ceramic is constituted by: piezoelectric ceramic layers which do not contain lead as a constituent element, have a perovskite compound expressed by the composition formula LiNaKNbO(where 0.02&#x3c;x&#x2264;0.1, 0.02&#x3c;x+y&#x2264;1) as the primary component, and contain 0.2 to 3.0 mol of Li relative to 100 mol of the primary component; and internal electrode layers which are constituted by a metal that contains silver by 80 percent by mass or more; wherein the multilayer piezoelectric ceramic is such that Li compounds other than the primary component are localized therein. The multilayer piezoelectric element can offer excellent insulating property.

Multilayer piezoelectric ceramic and method for manufacturing same, multilayer piezoelectric element, as well as piezoelectric vibration device

A piezoelectric ceramic, which does not contain lead as a constituent element, is characterized in that: its primary component is a perovskite compound expressed by the composition formula (BiNaBa)(TiMn)O(where 0.01&#x2264;x&#x2264;0.25, 0.001&#x2264;y&#x2264;0.020); and the coefficient of variation (CV) in grain size among the grains contained therein is 35 percent or lower. The piezoelectric ceramic presents an improved dielectric loss tangent tan &#x3b4;.

Piezoelectric ceramic and method for manufacturing same, as well as piezoelectric element

An anti-HSV monoclonal antibody or an antigen-binding fragment thereof is an anti-HSV gB monoclonal antibody or an antigen-binding fragment thereof that specifically binds to herpes simplex virus (HSV) envelope glycoprotein B (gB), comprising: a heavy chain variable region comprising a heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3, a heavy chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 4, and a heavy chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 5; and a light chain variable region comprising a light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6, a light chain CDR2 consisting of the amino acid sequence set forth in SEQ ID NO: 7, and a light chain CDR3 consisting of the amino acid sequence set forth in SEQ ID NO: 8.

Anti-HSV GB monoclonal antibody or antigen-binding fragment thereof

In an embodiment, a multilayer piezoelectric element includes a multilayer piezoelectric body and multiple internal electrodes. The multilayer piezoelectric body has a pair of principal faces in a first-axis direction, a pair of end faces in a second-axis direction crossing at right angles with the first-axis direction and defining the longitudinal direction, and a pair of side faces in a third-axis direction crossing at right angles with the first-axis direction and second-axis direction. The multiple internal electrodes are placed inside the multilayer piezoelectric body and stacked in the first-axis direction. Among the multiple internal electrodes, a center internal electrode placed at the center part of the multilayer piezoelectric body is such that its first cross-sectional shape, as viewed from the third-axis direction, has undulations greater than the undulations of the second cross-sectional shape of the center internal electrode as viewed from the second-axis direction.

A multilayer piezoelectric element includes a ceramic base body, a pair of external electrodes, multiple internal electrodes, and surface electrodes. The pair of external electrodes cover a pair of end faces and extend from the pair of end faces along a pair of principal faces and a pair of side faces. The multiple internal electrodes are stacked inside the ceramic base body along the thickness direction, and are connected alternately to one or the other of the pair of external electrodes along the thickness direction. The surface electrodes extend from the pair of external electrodes along the pair of principal faces, and are each divided in the longitudinal direction at a position near, of the pair of external electrodes, the external electrode to which the internal electrode adjacent to the principal face is connected.

A modified protein of a herpes simplex virus (HSV) envelope glycoprotein B (gB), in which at least one non-neutralizing antibody-inducing epitope (non-neutralizing epitope) present in domain IV and domain I of wild-type HSV gB is inactivated (de-epitoped).

Modified HSV gB protein and HSV vaccine including same

A multi-layer piezoelectric ceramic component includes: a piezoelectric ceramic body having a cuboid shape, having upper and lower surfaces facing in a thickness direction, first and second end surfaces facing in a length direction, and a pair of side surfaces facing in a width direction, and including first and second regions; first internal electrodes in the first region; second internal electrodes in the second region; third internal electrodes in the first and second regions; a first terminal electrode formed on the first end surface and electrically connected to the first internal electrodes; a second terminal electrode formed on the first end surface and electrically connected to the second internal electrodes; a third terminal electrode formed on the second end surface and electrically connected to the third internal electrodes; a first surface electrode formed on the upper surface; and a second surface electrode formed on the lower surface.

Multi-layer piezoelectric ceramic component and piezoelectric device

The modified HSV gD protein of the present invention is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD), wherein the modified HSV gD protein is derived from a wild-type HSV gD by modification of at least one of B cell epitopes having low or no neutralizing antibody-inducing activity compared to a B cell epitope present in a receptor-binding domain (RBD) (decotopes) in the ectodomain of the wild-type HSV gD, so that the modified epitope does not function as an epitope.

Modified HSV gD protein and vaccine containing same

A multi-layer piezoelectric ceramic component includes: a piezoelectric ceramic body having a cuboid shape having upper and lower surfaces facing in a thickness direction, first and second end surfaces facing in a length direction, and a pair of side surfaces facing in a width direction; first internal electrodes formed in the piezoelectric ceramic body and drawn to the first end surface; second internal electrodes formed in the piezoelectric ceramic body and drawn to the second end surface; a first terminal electrode formed on the first end surface; and a second terminal electrode formed on the second end surface, the first and second internal electrodes each having a width equal to a distance between the pair of side surfaces, at least one of the pair of side surfaces including a groove extending in non-parallel with the length direction.

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Tokyo, Japan

Hiroyuki Shimizu