Tohoku University

Mitsubishi Chemical Corporation

Hiroyuki Shibata

Kenji Shimoyama

Kazumasa Kiyomi

Hirobumi Nagaoka

Yoshiharu Iwabuchi

Yoshio Waseda

Hisatsugu Ohori

Hiroyuki Yamakoshi

Yuichi Kakudo

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.

Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, &#x3b2;-catenin-degrading agent, and p53 expression enhancer

Disclosed is a method of manufacturing a GaN-based material having high thermal conductivity. A gallium nitride-based material is grown by HVPE (Hydride Vapor Phase Epitaxial Growth) by supplying a carrier gas (G) containing Hgas, GaCl gas (G), and NHgas (G) to a reaction chamber (), and setting the growth temperature at 900 (&#xb0; C.) (inclusive) to 1,200 (&#xb0; C.) (inclusive), the growth pressure at 8.08&#xd7;10(Pa) (inclusive) to 1.21&#xd7;10(Pa) (inclusive), the partial pressure of the GaCl gas (G) at 1.0&#xd7;10(Pa) (inclusive) to 1.0&#xd7;10(Pa) (inclusive), and the partial pressure of the NHgas (G) at 9.1&#xd7;10(Pa) (inclusive) to 2.0&#xd7;10(Pa) (inclusive).

Gallium nitride-based material and method of manufacturing the same

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Miyagi-ken, Japan

Hiroyuki Shibata