Ube Industries, Inc.

Sanwa Kagaku Kenkyusho Co., Ltd.

Daiichi Sankyo Company, Limited

Hiroyuki Setoguchi

Yasunori Tsuzaki

Ryo Iwamura

Hiroto Akaza

Tomio Kimura

Masahiko Hagihara

Tsuyoshi Nakamura

Motohisa Shimizu

Noriaki Iwase

Yasuhito Yamamoto

Hidenori Namiki

Hidetoshi Sunamoto

Koji Ito

Katsunori Takata

Kenji Yoneda

Akira Takama

Naoki Terasaka

Kaori Taniko

Toshiyuki Miyazawa

Daisuke Kurumazuka

Satoko Harada

Toru Izuchi

Morio Okabe

Osamu Kikuchi

Yuka Kuno

Tatsuroh Kaneko

Yuuki Imura

Akiko Shima

Kazunari Tsuboike

Taniko Kaori

Harada Satoko

Izuchi Toru

Okabe Morio

Kurumazuka Daisuke

Kaneko Tatsuroh

Miyazawa Toshiyuki

Disclosed herein are a crystal comprising a compound, which has &#x3bc;-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal. The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein Ris a hydrogen atom or a halogen atom, and Ris a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.

Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof

The object of the present invention is to provide a compound having an antagonistic action against &#x3bc;-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:   

3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose

The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein Ris H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

Substituted pyridine compound

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Ube, Japan

Hiroyuki Setoguchi