Riken Corporation

Other

Snow Brand Milk Products Co., Ltd.

Rikagaku Kenkyusho

The Institute of Physical and Chemical Research

Japanese Foundation for Cancer Research

Institute of Biotechnology Applied To Soil Eumycetes

Hiroyuki Osada

Hideaki Kakeya

Tadao Asami

Takeshi Nakano

Akira Wada

Ayumi Yamagami

Susumu Kanazawa

Hiroshi Konno

Konstanty Wierzba

Takeshi Shimizu

Nobumoto Watanabe

Hiroki Hayase

Yujiro Hayashi

Taku Demura

Misato Ohtani

Kunihiro Ohta

Hidetoshi Takahashi

Shunji Takahashi

Yoshiyuki Sakaki

Gosei Kawanishi

Kiyoshi Isono

Makoto Kawatani

Atsushi Toyoda

Kaori Honda

Akiho Murayama

Yasumitsu Kondoh

Naoki Kanoh

Ryoji Yao

Siro Simizu

Kimie Kobinata

Hui-ping Zhang

This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Arrepresents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Arrepresents phenyl substituted with halogen; Rand Reach represent hydrogen, alkyl, cyano, or carboxyl; Rand Rmay together form oxo; Rto Reach represent hydrogen or methyl; and Rand R, Rand R, Rand R, and/or Rand Rmay together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.

Agent for inducing callus and method for inducing callus

The present invention concerns: a plant growth-promoting agent comprising a compound represented by Formula (I) or a salt thereof:  wherein Arrepresents a substituted or unsubstituted phenyl group, NZ represents a nitrogen-containing heterocyclic ring group or an acyclic nitrogen-containing group having a partial structure of the nitrogen-containing heterocyclic ring group, n is 0, 1, or 2, Rand Reach represent a hydrogen atom, a substituted or unsubstituted C-alkyl group, a cyano group, or a carboxyl group, Rand Rmay together form an oxo group, and when n is 2, Ror Rmay be the same or different; and a method for promoting plant growth using the plant growth-promoting agent.

Plant growth-promotion agent and method for promoting plant growth

According to the present invention, a transgenic plant, wherein expression of the BSS1 gene having activity to bind to a BIL1 protein to inhibit the transfer of the BIL1 protein into the nucleus so as to down-regulate brassinosteroid signaling is suppressed or promoted, and a method for regulating plant growth, wherein expression of the BSS1 gene in a plant body is suppressed or promoted, are provided.

Method for regulating plant growth

The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.

Anti-malarial agent

The invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine. 

The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine. 

Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5'-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5&#x2032;-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an RNA corresponding to the above-mentioned nucleic acid construct.

Nucleic acid construct, nucleic acid-protein complex, and use thereof

The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.

Small compounds targeting TACC3

A bacterium belonging to the genushaving an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.

Process for producing reveromycin A or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders

It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact with magnetic beads, on the surface of each of which a photoreactive compound has bound; extending the magnetic beads together with the compound on a support; and applying light to the magnetic beads to form a covalent bond between the photoreactive compound and the compound.

Method to prepare magnetic beads conjugated with small compounds

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.

Compound having antitumor activity and process for producing the same

A method of fixing a low-molecular compound to a solid-phase support, by bringing a solution containing a low-molecular compound into contact with a solid-phase support having a photoreactive compound bonded to the surface, evaporating the solution containing a low-molecular compound to dryness, in the state of being in contact with the solid-phase support, and irradiating the solid-phase support with light to form a covalent bond between the photoreactive compound and the low-molecular compound. This fixing method enables a low-molecular compound to be fixed to a solid-phase support without the aid of a functional group.

Method of fixing low-molecular compound to solid-phase support

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient. 

A compound represented by the following formula (I) or a salt thereof which has excellent antitumor activity and angiogenesis inhibitory action in a low oxygen condition, and a medicament such as an antitumor agent and an anti-inflammatory agent which comprises the compound or a physiologically acceptable salt thereof as an active ingredient. 

Growing community of inventors

Wako, Japan

Hiroyuki Osada