Ono Pharmaceutical Co., Ltd.

Sanyo Electric Co., Ltd.

Ono Pharmaceuticals Co., Ltd.

Ono Phramaceutical Co., Ltd.

Hiroyuki Ohno

Shuichi Ohuchida

Masaaki Toda

Yoshinobu Arai

Katsuhiro Imaki

Hisao Tajima

Narito Tateishi

Koichiro Kitagawa

Kazuo Kishimoto

Kazuyuki Ohmoto

Makoto Tanaka

Tohru Miyazaki

Masashi Kato

Takahiko Nakae

Kazuhito Kawabata

Takehito Fujita

Kaoru Kobayashi

Satoshi Narukawa

Hiroyuki Okuda

Ikuro Nakane

Takahiro Ogawa

Yutaka Ueta

Kousou Ishihara

Atsushi Furuzawa

Tsutomu Sonozaki

Takao Yamano

Tadashi Tatsumi

Yoshifumi Fukumoto

Kiyoyuki Sato

Toshinori Urano

Kazuhiro Koga

Kiyotaka Itou

Formula (I) compounds: wherein Ris alkyl substituted by fluorine(s); Ris hydroxy, alkoxy, alkoxy substituted by phenyl, NRR, in which R, Ris (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to Rand R, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof. Also, Formula (X) compounds: wherein n is 0 or 1, Ris hydrogen and chlorine, Ris R&#x2014;CH&#x2014; or R, or Rand R, taken together is alkylidene; Ris hydroxy, alkoxy, alkoxy substituted by phenyl, NRR, in which R, Ris (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to Rand R, taken together is a saturated heterocyclic ring or amino acid residue, Ris (i) F&#x2014;(CH)m- or FC&#x2014;CH&#x2014;, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; Ris alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy. Non-toxic and acid addition salts thereof are useful to prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) and neuronal dysfunction by stroke or traumatic injury (e.g., Multiple sclerosis).

Pentanoic acid derivatives

Formula (I) compounds: wherein Ris alkyl substituted by fluorine(s); Ris hydroxy, alkoxy, alkoxy substituted by phenyl, NRR, in which R, Ris (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl subsituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to Rand R, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof. Also, Formula (X) compounds: wherein n is 0 or 1, Ris hydrogen and chlorine, Ris R&#x2014;CH&#x2014; or R, or Rand R, taken together is alkylidene; Ris hydroxy, alkoxy, alkoxy substituted by phenyl, NRR, in which R, Ris (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to Rand R, taken together is a saturated heterocyclic ring or amino acid residue, Ris (i) F&#x2014;(CH)m- or FC&#x2014;CH&#x2014;, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; Ris alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy. Non-toxic and acid addition salts thereof are useful to prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) and neuronal dysfunction by stroke or traumatic injury (e.g., Multiple sclerosis).

The compound of the formula (I): wherein Ris alkyl substituted by fluorine(s); The compounds of the present invention of the formula (I) and the compounds of the formula (X): wherein n is 0 or 1,

Fused pyrazine compounds

Polypeptide of protein p140 and DNAs encoding it

Tetrazole compounds and pharmaceutical agents containing such derivative as an active ingredient

The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the polypeptide; vector derived with the DNA; host cells transformed with the vector; antibody of the polypeptide; pharmaceutical composition containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and the screening methods of the prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).

Polypeptide of protein P140 and DNAs encoding it

Tetrazole compounds and pharmaceutical agents containing such derivative

In a thin type sealed cell utilizing a cell case made of a laminated material, a storage life and reliability of the cell is increased by preventing a sectional surface at an end of the laminated material from being exposed in the cell case, and thereby a leakage of an electrolyte out of the cell and a short circuit in the cell are avoided. This is achieved by disposing a resin layer on the inner surface of the cell case composed of a sheet type laminated material, and covering the sectional surface existing inside the cell case with resin.

Thin type sealed cell and producing method thereof

A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.

Sulfonamide derivatives

The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).

Polypeptide of protein P140 and DNAS encoding it

A magnetic head comprises a first abutting segment formed with a winding groove having an open side, and a second abutting segment opposed to the open side of the groove and joined to the first segment. The first abutting segment comprises a first core segment having the groove, and gap spacers and second ferromagnetic thin films formed on the surface thereof opposed to the second segment and positioned above and below the groove. The first core segment comprises a core segment member made of a ferromagnetic material, formed with the groove and having a first ferromagnetic thin film which is formed on the surface thereof opposed to the second abutting segment and which is positioned toward the face of the head to be opposed to recording media. The second abutting segment has a face to be opposed to the recording medium and formed by a nonmagnetic material.

Magnetic head for magnetic recording and reproduction

A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1.beta. converting enzyme (ICE).

Tetrazole compound

Growing community of inventors

Shiga, Japan

Hiroyuki Ohno