Ube Industries, Inc.

Nissan Chemical Industries Limited

Tokuyama Corporation

Hiroyuki Oda

Shigeyoshi Nishino

Hidetaka Shima

Kenji Hirotsu

Takashi Harada

Katsumasa Harada

Shuji Yokoyama

Tetsuro Shimano

Takeshi Takahashi

Yoji Omata

Shizuo Tokito

Toshikazu Machida

Akira Nakamura

Daisuke Kumaki

Yasuhiro Tanaka

Takenori Isomura

Shinobu Suzuki

Kazuaki Kakita

Yasuhiro Yoneda

Youji Omata

Naoko Okada

Shinya Takigawa

Ryosuke Nishimoto

Daisuke Abiko

Provided is a method for producing a halogenated hydrocarbon magnesium compound, the method including bringing a halogenated hydrocarbon compound into contact with magnesium having a specific surface area of 1×10to 2×10m/g. Also provided are methods for producing a tertiary alcohol compound and an organosilicon compound, wherein said production method is utilized.

Method for producing halogenated hydrocarbon magnesium compound and methods for producing tertiary alcohol compound and organosilicon compound

An aryloyl(oxy or amino)pentafluorosulfanylbenzene compound having pharmacological action. The aryloyl(oxy or amino)pentafluorosulfanylbenzene compound is represented by general formula (A-I), a pharmaceutically acceptable salt thereof, and a prodrug thereof, wherein all of parameters represent the same meanings as defined in the specification.

Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof

A benzobis(thiadiazole) derivative represented by the formula (1): 

Benzobis(thiadiazole) derivative and organic electronics device comprising same

A process for producing a quinazolin-4-one compound having the formula: [wherein R, R, Rand Reach represents a group not participating in the below-mentioned reaction, and R, R, Rand Rcan be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein Ris a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.

Process for producing quinazolin-4-one derivative

A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R&#x2014;NH&#x2014;R(each of Rand Rrepresents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.

Process for producing 4-aminoquinazoline compound

6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate: 

Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one

A polycyclic pentafluorosulfanylbenzene compound represented by the following general formula (1) and a process for producing the polycyclic pentafluorosulfanylbenzene compound which comprises reacting a specific pentafluorosulfanylbenzene compound with a specific boronic acid compound are provided. The polycyclic pentafluorosulfanylbenzene compound is a novel compound and can be produced by the process industrially advantageously. (Rto Reach independently represent hydrogen atom or fluorine atom, Rrepresents a hydrocarbon group having at least two cyclic structures which may have substituents, and Z represents keto group, thioketo group, methylene group or difluoromethylene group.)

Polycyclic pentafluorosulfanylbenzene compound and process for producing the compound

Disclosed is a commercially suitable method for producing a 1-substituted-5-acylimidazole compound. A 1-substituted-5-acylimidazole compound is produced with a high position selectivity by reacting an N-substituted amidine compound or a salt thereof with a ketone compound in the presence of a base.

Method for producing 1-substituted-5-acylimidazole compound

A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2): 

5-fluorooxindole-3-carboxylic acid ester

A process for preparing quinazolin-4-one or its derivative by reacting anthranilic acid or its derivative with formic acid or its derivative in the presence of ammonia, or by reacting ammonium anthranilate or its derivative with formic acid or its derivative.

Process for producing quinazolin-4-one and derivatives thereof

The present invention discloses a process for preparing 5-fluorooxindole represented by the formula (3):which comprises (A) a first step of cyclizing 2-(5-fluoro-2-nitrophenyl)malonic acid diester represented by the formula (1):

Process for producing 5-fluorooxindole and for producing intermediates therefor

2-Cyclopropyl-4-(4'-fluorophenyl)quinoline-3-carboxyaldehyde useful as a material for pharmaceutical products, can be obtained by reacting 3-cyclopropyl-3-oxopropanenitrile with 2-amino-4&#x2032;-fluorobenzophenone to obtain 2-cyclopropyl-4-(4&#x2032;-fluorophenyl)quinoline-3-carbonitrile, and reducing it.

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Yamaguchi, Japan

Hiroyuki Oda