Daiichi Sankyo Company, Limited

Mizusawa Kagaku Kogyo Kabushiki Kaisha

Ricoh Company, Ltd.

Daiichi Pharmaceutical Co., Ltd.

Other

Mizusawa Industrial Chemicals, Ltd.

Mitsubishi Corporation

Suzuki Sangyo Co., Ltd.

Shizu Naito

Yamato Refractives & Co.

Mitsubisha Corporation

Mizusawa Kazahu Kogyo Kabushiki Kaisha

Mizusawa Kagaku Kozyo Kabushiki Kaisha

Hiroyuki Naito

Yujiro Sugahara

Hideki Miyazaki

Takeshi Masuda

Masao Yoshida

Yuji Kasuya

Takashi Nakada

Yuki Abe

Shinji Ashida

Yusuke Ogitani

Koji Morita

Yoshibumi Noshi

Yoshihiro Norikane

Hiroshi Iwata

Tatsuya Niimi

Takashi Matsumura

Kiyoshi Takai

Akira Takahashi

Hitoshi Ohki

Akio Ejima

Ichiro Hayakawa

Satoru Ohsuki

Kouichi Uoto

Mamoru Saito

Makoto Ono

Hideyuki Kanno

Kenji Yoshikawa

Satoshi Komoriya

Noriyasu Haginoya

Tsutomu Nagata

Masatoshi Nagamochi

Toshiharu Yoshino

Kenji Sugiura

Keisuke Shiba

Jun Watanabe

Keisuke Yoshida

Kentaro Ito

Tomio Suzuki

Yuuichi Sugimoto

Yoshiko Kagoshima

Noriaki Okada

Hisashi Tuchida

Syozo Kobayashi

Akiyoshi Mochizuki

Toshiharu Ohta

Yumi Nakamoto

Masaaki Sugawara

Takashi Maruya

Masaki Miyazaki

Katsuhiro Kobayashi

Shigehisa Imafuku

Saito Higuchi

Tsuneo Kasugai

Ryutaro Kanada

Yuki Shingai

Kimie Watanabe

Noboru Maruyama

Masanori Ito

Hideyo Ohmori

Kyugo Gotoh

Takashi Mori

Toshio Honma

Tatuya Kondo

Akiko Egami

Hisashi Tsuchida

Manshiro Hasegawa

Takashi Suzuki

Masayoshi Asano

Masashi Aonuma

Yoshihito Shimada

Chie Makino

Akifumi Nakamura

Makoto Haruta

Katsuya Toki

Nobuhiko Minagawa

Yasushi Hamada

Shoji Shoji

Seiichi Nakamura

Hideaki Funami

Nobuo Omori

Tokio Okubo

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH—(CH)n-L-L-L- wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

Antibody-drug conjugate

Provided is an inkjet active-energy-ray-curable composition including a bisphenol-type methacrylate, a low-viscosity monomer, and an inorganic filler.

Inkjet active-energy-ray-curable composition, three-dimensional object producing method, and three-dimensional object producing apparatus

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as the connecting position

Method for treating cancer comprising administration of anti-HER2 antibody-drug conjugate

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-L-L- wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as the connecting position. 

Method of treating cancer comprising administration of anti-HER2 antibody-drug conjugate

The present invention provides a compound having excellent histone acetyl transferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: 

EP300/CREBBP inhibitor

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L-L-L-NH&#x2014;(CH)n-L-L-Lor -L-L-L- wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the terminal Lor Lwith the nitrogen atom of the amino group at position 1 as the connecting position. 

(Anti-HER2 antibody)-drug conjugate

Provided is an active-energy-ray-curable liquid composition containing a monomer (A) having a hydrogen-bonding capacity and a solvent (B) having a hydrogen-bonding capacity, wherein the active-energy-ray-curable liquid composition satisfies conditions below, &#x3c;Conditions&#x3e; a cured product obtained by irradiating the active-energy-ray-curable liquid composition with 500 mJ/cmof an active energy ray is a solid having a compressive stress of 2.0 kPa or greater when compressed by 1% at 25 degrees C., and the cured product has a water decaying property.

Active-energy-ray-curable liquid composition, three-dimensional object forming material set, method for producing three-dimensional object, and three-dimensional object producing apparatus

A method of manufacturing a three-dimensional object includes imparting a first liquid having a first composition including a solvent and a curable material and a second liquid having a second composition to form a liquid film, curing the liquid film, and repeating the imparting and the curing to obtain the three-dimensional object, wherein the imparting position and the imparting amount of each of the first liquid and the second liquid are controlled in such a manner that the liquid film includes multiple areas where at least one of post-curing compression stress and post-curing modulus of elasticity is different.

Method of manufacturing three-dimensional object, liquid set for manufacturing three-dimensional object, device for manufacturing three-dimensional object, and gel object

A solid freeform fabrication object includes a hydrogel including a polymer, water, and a coloring material inclusion substance.

Solid freeform fabrication object, internal organ model, and method of manufacturing the same

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-L-L- or -L-L-L- wherein the antibody is connected to the terminal of L, the antitumor compound is connected to the terminal of Lor L, and any one or two or more of linkers of L, L, and Lhas a hydrophilic structure.

Antibody-drug conjugate produced by binding through linker having hydrophilic structure

Provided is a bolus formed of a hydrogel, wherein the hydrogel includes water, a polymer, and a mineral, and wherein the bolus is applied to a patient who receives a radiation therapy.

Bolus and method for producing same

An active energy ray liquid composition is provided. A cured product of the active energy ray curable liquid composition is a solid at 25&#xb0; C. and a liquid at 60&#xb0; C., and the solid exhibits a compression stress of 2.0 kPa or more when compressed 1%.

Active energy ray curable liquid composition, method for manufacturing three-dimensional objects, and apparatus for manufacturing three-dimensional objects

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula:-L-L-L-NH&#x2014;(CH)-L-L-L-wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

Growing community of inventors

Tokyo, Japan

Hiroyuki Naito