Kyowa Hakko Kogyo Co., Ltd.

Hiroyuki Nagata

Isami Takahashi

Yutaka Kanda

Tsutomu Akama

Yutaka Saitoh

Kenichi Mochida

Shun-ichi Ikeda

Atsuhiro Hasegawa

Harumi Ue

Yusuke Nakamura

Katsuhiko Ando

Keiko Ochiai

Tatsuya Tamaoki

Hiromasa Miyaji

Toshio Ota

Mayumi Yoshida

Sumio Sugano

Ayako Kawabata

Yumiko Aotani

Motoko Haruoka

The present invention relates to a novel phospholipase Apolypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase Apolypeptide. The present invention also relates to a method of utilizing the polypeptide, e.g., a method of screening for a compound having agonist or antagonist activity by using the polypeptide or an antibody to the polypeptide, and a pharmaceutical comprising the polypeptide or an antibody to the polypeptide. The present invention further relates to a polypeptide inhibiting the phospholipase Aactivity of a phospholipase Apolypeptide (hereinafter referred to as inhibitor polypeptide), DNA encoding the inhibitor polypeptide, a vector comprising the DNA encoding the inhibitor polypeptide, a transformant transformed with the vector, a pharmaceutical comprising the inhibitor polypeptide, and a process for producing the inhibitor polypeptide.

[object Object]

LK6-A derivatives

Pyrrolo &lsqb;4,3,2-de&rsqb; quinoline derivatives

The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.

Compound LK6-A

Growing community of inventors

Sunto-gun, Japan

Hiroyuki Nagata