Shimadzu Corporation

Hiroyuki Miura

Hideaki Izumi

Yusuke Tateishi

Yoshihiro Ueno

Kiyoshi Ogawa

Ryugo Maeda

An MT-TOFMS which is one mode of the present invention includes: a linear ion trap () configured to temporarily hold ions to be analyzed, and to eject the ions through an ion ejection opening () having a shape elongated in one direction; a loop flight section () configured to form a loop path (P) capable of making ions repeatedly fly; and a slit part () located on an ion path in which the ions ejected from the linear ion trap () travel until the ions are introduced into the loop path, the slit part configured to block a portion of the ions in a longitudinal direction of the ion ejection opening ().

Multi-turn time-of-flight mass spectrometer

A mass spectrometerincludes a vacuum containerdivided into a first chambercontaining an ion trapand a second chambercontaining a time-of-flight mass spectrometer. The ion trapis held within an ion-trap-holding spacesurrounded by a wall. In this wall, a cooling-gas discharge portis formed in addition to an introduction-side ion passage portand an ejection-side ion passage port. A cooling gas supplied into an ion-capturing spaceof the ion trapis discharged from the ion-trap-holding spacethrough the three ports. The provision of the cooling-gas discharge portreduces the amount of cooling gas flowing into the ejection-side ion passage portand interfering with the ejection of ions from the ion trapinto the time-of-flight mass spectrometer. Consequently, the detection intensity of the ions is improved.

Mass spectrometer

Provided is a time-of-flight mass spectrometer including: a loop-orbit defining electrode () including an outer electrode () and inner electrode () located on the outside and inside of a loop orbit, respectively; an ion inlet (); an ion outlet () provided in either the outer or inner electrode; a loop-flight voltage applier () configured to apply loop-flight voltages to the outer and inner electrodes, respectively; a set of deflecting electrodes () facing each other across a section of an n-th loop orbit, where n is a predetermined number, the deflecting electrodes including a first portion () which faces the n-th loop orbit and a second portion () which includes other portions; and a voltage applier () configured to apply deflecting voltages to the first portion so as to reverse the drifting direction of the ions flying in the n-th loop orbit, and a voltage to the second portion so as to create the loop-flight electric field.

Time-of-flight mass spectrometer

Provided is a method for mass spectrometry in which ions to be analyzed are made to come in contact with a cooling gas in a cooling section, such as an ion trap, configured to perform the cooling of ions, and kinetic energy is subsequently imparted to the ions so as to introduce the ions into a flight space of a multi-turn time-of-flight mass separatoror similar device for separating ions according to their mass-to-charge ratios. According to the present invention, when a known or estimated number of charges of an ion to be analyzed is high, the amount of supply of the cooling gas to the cooling section is set to a lower level than when the number of charges is low. This operation improves the detection sensitivity for ions having large molecular weights and high numbers of charges.

Method for mass spectrometry and mass spectrometer

To compensate for the distortion of the loop-flight electric field with a higher level of accuracy, a multiturn time-of-flight mass spectrometerincludes: a main electrodeconfigured to generate, within a predetermined loop-flight space, a loop-flight electric field which is an electric field that makes an ion fly in a loop orbit multiple times, the main electrode having an openingorthrough which ions are introduced into or extracted from the loop-flight space; a compensating-electrode attachment partmade of an insulating material and fixed to the main electrode; and a compensating electrodeconfigured to compensate for a distortion of the loop-flight electric field which occurs in the vicinity of the opening, the compensating electrode being fixed to the compensating-electrode attachment part directly or via a substrateand located in the vicinity of the opening.

Multiturn time-of-flight mass spectrometer and method for producing the same

A microchannel plate (MCP)in an ion detection sectionmultiplies electrons. An anodedetects those electrons and produces a current signal. An amplifierconverts this signal into a voltage signal. A low-pass filterA acting as a smoothing sectionis located at the output end of the amplifier. A waveform-shaping time adjusteradjusts the time constant of the low-pass filterA beforehand according to the response time of the MCP, mass-to-charge ratio of an ion species to be subjected to the measurement, and duration of the spread of the ion species which depends on device-specific parameters. A plurality of peaks which sequentially appear in the detection signal corresponding to one ion species are thereby smoothed into a single broad peak. Thus, the distinguishability between signal waves and noise components is improved.

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Kyoto, Japan

Hiroyuki Miura