Fuji Photo Film Company, Limited

Fujifilm Corporation

Hiroyuki Komazawa

Masayoshi Kojima

Naoyuki Nishikawa

Masayuki Kawakami

Ichiro Azuma

Kazuhisa Ono

Tsunehiro Aki

Atsushi Orikasa

Ikuo Saiki

Mitsunori Ono

Hideto Mori

Hiroshi Kitaguchi

Hideaki Satoh

An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides astrain which has an ability of producing docosahexaenoic acid, and use thereof.

Microorganism having an ability of producing docosahexaenoic acid and use thereof

There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

Amino acid derivatives and application thereof

A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;

Tumor metastasis inhibiting compounds and methods

A CM-chitin derivative which has, as an essential unit, a cohesive peptide represented by the following general formula (I), bonded to the side chain of CM-chitin, wherein the bond connecting CM-chitin and said peptide is selected from the group consisting of an amido bond, an ester bond, an ether bond and a urethane bond:

CM-chitin derivatives and use thereof

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Asaka, Japan

Hiroyuki Komazawa