Shimano Inc.

Ptc Therapeutics, Inc.

Sumitomo Pharma Co., Ltd.

Sumitomo Dainippon Pharma Oncology, Inc.

Hiroyuki Kitano

Kazuto Mori

Tomoyuki Furuta

Hajime Seki

Yohei Kobayashi

Chiang Jia Li

Hiroaki Tanaka

Hitoshi Ban

Takeshi Ueda

Yoshiaki Isobe

Yoshiyuki Kasai

Yuichiro Ishikawa

Tomoyuki Tanaka

Seiji Kamioka

Yu Goto

Yuichi Ueyama

Shun Narai

Shoukou Ri

Provided is a 2-heteroaryl aminoquinazolinone derivative, which is a compound represented by formula (1): or a pharmaceutically acceptable salt thereof wherein Xrepresents CRor N, Xrepresents CRor N, Xrepresents CRor N, Xrepresents CRor N, Y represents optionally substituted Calkyl, an optionally substituted Calicyclic group, an optionally substituted 4- to 10-membered nitrogen-containing non-aryl heterocycle, optionally substituted Caryl, or optionally substituted 5- to 10-membered heteroaryl, Z represents optionally substituted 6- to 10-membered heteroaryl, and R, R, R, and Reach independently represent a hydrogen atom, halogen, cyano, optionally substituted Calkyl, optionally substituted Calkoxy, or the like.

2-heteroaryl aminoquinazolinone derivative

Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotropic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof.

2-substituted amino-naphth (1,2-d) imidazol-5-one compounds of pharmaceutically acceptable salts thereof

The present invention relates to a medicament for treating various nervous system diseases or psychiatric diseases, comprising a compound of formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein Ris hydrogen, etc., Ris halogen, etc., R, R, R, and Rare hydrogen, etc. 

Benzisoxazole derivative

A human-powered vehicle control device includes first and second rotary bodies, a transferring member that transfers drive force between the first and second rotary bodies, and a component. At least one of the first and second rotary bodies includes a plurality of rotary bodies. The component includes a transmission that performs a shifting action to move the transferring member between the plurality of rotary bodies. The control device includes an electronic controller controls the shifting action in accordance with a control condition set based on a travel state of the human-powered vehicle and/or a state of a rider. The electronic controller includes a first state that determines whether the control condition is satisfied and a second state that does not determine whether the control condition is satisfied. The electronic controller switches between the first and second states in accordance with a rotational state of the plurality of rotary bodies.

Human-powered vehicle control device and human-powered vehicle transmission system

A user interface of a bicycle derailleur is configured to receive a user input to execute at least one of: calibration in which a sensor is reset; changing an assist operation of an assist driving unit; changing information displayed in a display; a recovering operation by an actuator of the bicycle derailleur; a reset of a pairing operation; changing a shifting threshold used in an automatic shifting mode; changing a communication channel between a wired communication channel and a wireless communication channel; changing a function assigned to an operating device; a shut-down of a system of the bicycle derailleur; a wake-up operation of the system; a restart of the system; an operation of at least one additional bicycle component; changing a shifting mode between the automatic shifting mode and a manual shifting mode; and changing the shifting operation between a synchronized shifting mode and a non-synchronized shifting mode.

Bicycle derailleur

Provided is a 2-heteroaryl aminoquinazolinone derivative, which is a compound represented by formula (1): 

Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof. 

This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O, S, or N&#x2014;R; ring G is a 5-membered or 6-membered aromatic ring, etc., including 1-3 heteroatoms selected from O, S and N as constituent atoms; Rand Rare each independently a hydrogen atom, a halogen atom, or an optionally-substituted Calkyl carbonyl group, etc.; R, Rand Rare each independently a hydrogen atom, a halogen atom, or an optionally-substituted Calkyl carbonyl group, etc.; and Ris a hydrogen atom or an optionally-substituted Calkyl group, etc.]. 

Tricyclic quinone derivative

2-substituted amino-naphth (1,2-d) imidazol-5-one compounds or pharmaceutically acceptable salts thereof

A braking device for a dual-bearing reel for braking a spool rotatably mounted on a reel body, includes a spool brake and a spool controller. The spool brake is configured to brake the spool by electromagnetic induction during casting of a fishing line. The spool controller is configured to control a braking force of the spool brake by controlling an ON/OF-state of current that is generated due to the electromagnetic induction at a prescribed period. The spool controller has a period changer configured to change the prescribed period for braking the spool.

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Osaka, Japan

Hiroyuki Kitano