Fujisawa Pharmaceutical Company, Ltd.

Nissan Jidosha Kabushiki-kaisha

Mazda Motor Corporation

Nippon Electric Co., Ltd.

Nippon Telegraph and Telephone Public Corporation

Kyb Corporation

Oiles Corporation

Hiroyuki Kikuchi

Takashi Matsuura

Katsunori Saito

Noboru Nakagawa

Souichi Maruyama

Atsushi Iwata

Ilwon Lee

Keizo Yoshida

Toshihiko Sekine

Kazuhiko Akeda

Tatsuo Nagasaka

Fumiko Hamaguchi

Gaku Ikeyama

Junya Kuwagaki

Yasuji Yamada

Masanori Fukushima

Takashi Fujii

Toshitaka Manda

Osamu Hirai

Jun Ouchi

Tomonori Taniguchi

Mitsuhiko Fujikake

Takuzo Ito

Hiroki Masuda

Kazuya Sato

Yoshimitsu Fumimoto

Masaki Takahashi

Yoshiharu Shigeta

Yasumasa Tsukitani

Iwao Shimizu

Nobuo Kawaguchi

Hideaki Shiokawa

Sadao Ohki

Sho Yamaguchi

A clearance is created between an inner circumference of a bushing main body () which surrounds a rack () across a row of rack gear teeth () and an outer circumference of the rack (), and two supporting surfaces (A,B) which face each other with a bushing main body axis O therebetween and a supporting surface (C) which faces a back surface of the rack (), each extending along an x-axis direction, are formed on the inner circumference of the bushing main body (). The rack () in a neutral state is supported by the two supporting surfaces (A,B) so as to be displaceable along a z-axis direction, and the rack () in operation is stably supported by the three supporting surfaces (A-C) at three places. A groove bottom position of an annular elastic member attachment groove (), which is formed on an outer circumference of the bushing main body (), is offset toward the support surface (B) only in an area on a support surface (B) side from the bushing main body axis O, and therefore an elastic ring () attached to the elastic member attachment groove (), protrudes above an outer circumferential surface of the bushing main body (), but only in the area on the support surface (B) side from the bushing main body axis O.

Rack bushing and steering device

Console box for automobile

Instrument panel for automobile

The frequency divider includes a first or prescaling counter which selects between first and second frequency division factors, in response to a first control signal, and then divides an input signal frequency responsive to the first control signal. A second and programmable counter frequency divides the output of the first or prescaling counter by a third frequency-division factor. A third and programmable counter frequency divides the output of the first counter by a fourth frequency-division factor which is smaller than the third frequency-division factor. A switching control circuit then converts the output of the third counter and supplies the converted signal to the first counter, as the first control signal. The digital frequency divider is suitable for use a part of a phase-locked loop frequency synthesizer.

Digital frequency divider suitable for a frequency synthesizer

Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

Clavulone derivatives, process for preparing the same, and use of said

Adenosine derivatives of the general formula: ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which R.sup.5 and R.sup.6 are each hydrogen, alkoxy or arylthio and R.sup.7 is hydrogen or halogen, or a group of the formula: ##STR3## and R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkanoyl, and pharmaceutically acceptable salt thereof. These derivatives and salts thereof are useful as antihypertensives, bradycardiacs, etc. The method of production thereof and pharmaceutical compositions based on those adenosine derivatives or salts are also described.

Adenosine derivatives

Hyaluronidase obtained from Streptomyces koganeiensis has the following characteristics:

Novel hyaluronidase BMP-8231 and production thereof

Compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or methyl, providing that when R.sub.1 is hydrogen, R.sub.2 is hydrogen, have been found to be useful in relieving allergic symptoms by inhibiting histamine-release from mast cells. They can be used in free form or in the form of pharmaceutically acceptable acid addition salts.

Antiallergic methods

Growing community of inventors

Tokyo, Japan

Hiroyuki Kikuchi