Dainippon Ink and Chemicals, Incorporated

Hiroyuki Fukui

Hidetsugu Takagaki

Nobuyuki Kimura

Nahoko Muratake

Ryuji Kubota

Kouki Obata

Hiroshi Araya

A quinolinone derivative pharmaceutical composition comprising a quinolinone derivative represented by the structural formula (I): wherein the quinolinone derivative is in the form of particles, which have an average particle diameter of 0.5 to 10 &#x3bc;m and such a particle size distribution that particles having a particle diameter of 15 &#x3bc;m or less account for 90% or more of the totality of the particles, and also have a fusion enthalpy of 30 J/g or more, and the surface of the particles are coated with a water-soluble composition containing a water-soluble polymer, can quickly dissolve an active ingredient in the digestive tract and is also superior in long-term storage stability.

Quinolinone derivative pharmaceutical compositon and production method therefor

The problem to be solved by the present invention is to provide a quinolinone derivative formulation, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I), which is useful as a pharmaceutical, and particularly as an antiallergic, which has superior bioabsorption and stability. The present invention provides a quinolinone derivative, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I):

Quinolinone derivative formulation and its production method

Quinolinone derivative preparations and process for producing the same

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Sakura, Japan

Hiroyuki Fukui