Mercian Corporation

Sanraku Incorporated

Hiroyuki Chiba

Takeo Yoshioka

Rokuro Okamoto

Yasuo Fukagawa

Hiroshi Tone

Norio Shibamoto

Yoshio Watanabe

Azuma Watanabe

Kaichiro Kominato

Hitosi Agematu

Kohki Kiyoshima

Hiroshi Nishida

Toshihiko Kumamoto

Rei Kaneto

Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a pharmaceutical composition comprising one of these antibiotics and useful as an antifungal agent. ##STR1##

Antibiotics Mer-AF1032A and Mer-AF1032B

Tylosin derivatives represented by the following general formula (I): ##STR1## [wherein R denotes a hydrogen atom, acetyl, propionyl or a radical of Si(R.sup.2).sub.3 (in which R.sup.2 is a lower alkyl group), and R.sup.1 stands for a hydrogen atom or a radical of Si(R.sup.2 .sub.3 ] are useful as intermediates for the synthesis of 4'-acyl derivatives of tylosin because, after introduction of any desired acyl group at the 4'-hydroxyl group, the silyl protective group can be readily removed without liberation of the acyl group. This invention also provides processes for producing the tylosin derivatives. More specifically, it provides a melthod of selectively protecting 2'- and 4''-hydroxyl groups of tylosin (those of higher reactivity among the hydroxyl groups involved); a method of selectively protecting only the 4''-hydroxyl group of tylosin; a method of selectively protecting the 3- and 4''-hydroxyl groups of 2'-O-acyltylosin; and a method of protecting 3-, 2'- and 4''-hydroxyl groups of tylosin.

Tylosin derivatives and processes for producing the same

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Yokohama, Japan

Hiroyuki Chiba